Relevance of genetic polymorphisms of the human cytochrome P450 3A4 in rivaroxaban-treated patients

Ercisli, Muhammed; Lechun, Gao; Azeez, Sarhang; Hamasalih, Rebwar Muhammad; Song, Siyan; Aziziaram, Zahra

doi:10.55705/cmbr.2021.138880.1003

Cited by 15 publications

(12 citation statements)

References 16 publications

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“…It indicated that Dex can reduce the incidence of cognitive dysfunction under CPB cardiac surgery. Dex can improve immunity and reduce inflammation (18)(19)(20). After cardiac surgery under CPB, the complement system was activated, which stimulated the release of inflammatory factors, and caused inflammation.…”

Section: Results Of Fluorescence Quantitative Pcrmentioning

confidence: 99%

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Dong¹,

Li²,

Wang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The study aimed to explore the influence of Dexmedetomidine (Dex) on cognitive function and inflammatory factors in rats after cardiac surgery under cardiopulmonary bypass (CPB). For this purpose, 30 healthy male SD rats were reared in a quiet and clean environment with alternating light for 12 hours. They were rolled randomly into 3 groups, each with 10 rats, namely the control (Ctrl) group, the experimental group, and the Dex group. The rats in the Ctrl were not treated, and the rats in the experimental group were intraperitoneally injected with 50μg/kg saline. After that, cardiac surgery was performed under CPB. Rats in the Dex group were injected with 50 μg/kg Dex intraperitoneally and underwent cardiac surgery under CPB. The Morris water maze (MWM) experiment was performed to test the learning and memory abilities and spatial positioning abilities of SD rats. Enzyme-linked immunosorbent assay (ELISA method) was adopted to detect the contents of TNF-α, IL-6, and IL-1β. Fluorescence quantitative PCR was applied to determine the mRNA expression levels of TNF-α, IL-6, and IL-1β in the hippocampus. Results showed that in the MWM experiment, in contrast with the Ctrl, the escape latency of the experimental group and the Dex group after surgery were prolonged (P<0.05), and the times they crossed platforms reduced (P<0.05). In contrast with the experimental group, the escape latency of the Dex group shortened, and the times they crossed platforms increased. ELISA suggested that in contrast with the experimental group, the concentrations of TNF-α, IL-6, and IL-1β in the Ctrl decreased (P<0.05), and those in the Dex group decreased slightly. In the fluorescence quantitative PCR experiment, in contrast with the experimental group, the mRNA expression levels of TNF-α, IL-6, and IL-1β in the Ctrl increased, and those in the Dex group decreased slightly. Then Dex can improve the cognitive dysfunction of rats undergoing cardiac surgery under CPB, and its molecular mechanism may be to reduce the inflammation around the heart and hippocampus.

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Section: Results Of Fluorescence Quantitative Pcrmentioning

confidence: 99%

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Dong¹,

Li²,

Wang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…Microbial infections, heart diseases, and cancers are the main health-threatening diseases worldwide [1][2][3]. Antibiotic resistance is a threat in many hospitals, and mortality and death due to infections in patients are increasing dramatically [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antibiotic resistance and prevalence of multi-antibiotic resistant genes among Acinetobacter baumannii strains isolated from patients admitted to al-yarmouk hospital

Abbas-Al-Khafaji

Aubais-aljelehawy

2021

Cell. Mol. Biomed. Rep.

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Emerging antibiotic resistance in microorganisms particularly multidrugresistant bacterial strains are increasing because of misusing antibiotics as well as the evolution of antibiotic resistance mechanisms in new strains. In this regard, Acinetobacter baumannii is one of the six most common multidrugresistant microorganisms related to nosocomial diseases. Recently, carbapenems, as common antibiotics to treat infections caused by Acinetobacter have not shown an acceptable efficiency because of the resistance emergence to carbapenems in many strains of this bacterium. In this study, resistant strains of A. baumannii were isolated and identified as an appropriate preventive strategy to reduce bacterial infections in al-yarmouk hospital of Iraq. Disc diffusion test and PCR method were used to isolate of resistant strains and identify beta-lactamase genes of blaAmpC, blaTEM, blaVIM, and blaSHV. This study showed that these genes were contributed to the antibiotic resistance with about 18.4% and ≥53.5% strains expressing all 4 genes and ≥3 genes, respectively. The blaAmpC gene is more prevalent than other genes, and this is probably due to the prevalence or rapid transfer of this beta-lactamase. However, more studies should be performed in a comparative way to isolate and identify other antibiotic-resistant bacterial strains associated with other hospitals. Article info

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“…Recently, a few SNPs were described for the CYP3A4 and CYP3A5 genes. The CYP3A5*3 and CYP3A5*6 alleles were found to be the underlying cause for alternative splicing and protein truncation, resulting in the absence of functional CYP3A5 from liver tissue 33 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Genetic and Epigenetic Basis of Drug-Induced Liver Injury

et al. 2023

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Drug induced liver injury (DILI) is a rare but severe adverse drug reaction seen in pharmacotherapy and a major cause of post-marketing drug withdrawals. Advances in genome-wide studies indicate that genetic and epigenetic diversity can lead to inter-individual differences in drug response and toxicity. It is necessary to identify how the genetic variations, in the presence of environmental factors can contribute to development and progression of DILI. Studies on microRNA, histone modification and DNA methylation, SNPs related to DILI were retrieved from databases and were analyzed for the current research and updates develop this narrative review. We have compiled some of the major genetic, epigenetic, pharmacogenetic factors leading to DILI. Many validated genetic risk factors of DILI, such as variants of drug-metabolising enzymes, HLA alleles and some transporters were identified. In conclusion, these studies provide useful information in risk alleles identification and implementing personalised medicine.

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Relevance of genetic polymorphisms of the human cytochrome P450 3A4 in rivaroxaban-treated patients

Cited by 15 publications

References 16 publications

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Evaluation of antibiotic resistance and prevalence of multi-antibiotic resistant genes among Acinetobacter baumannii strains isolated from patients admitted to al-yarmouk hospital

Genetic and Epigenetic Basis of Drug-Induced Liver Injury

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