Relevance of GSTM1, GSTT1 and GSTP1 Gene Polymorphism to Breast Cancer Susceptibility in Mizoram Population, Northeast India

Kimi, Lalro; Ghatak, Souvik; Yadav, Ravi Prakash; Chhuani, Lalhma; Lallawmzuali, Doris; Pautu, Jeremy L.; Kumar, Nachimuthu Senthil

doi:10.1007/s10528-015-9698-5

Cited by 22 publications

(12 citation statements)

References 12 publications

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“…Findings of this study are contrary to what have been seen among Indians (Kimi et al, 2016), Brazilians (Possuelo et al, 2013), Caucasians (Zheng et al, 2002), Dutch (van der Hel et al, 2004), and French (Lizard-Nacol et al, 1999. The lack of association of GSTM1 null genotype with breast cancer has also been seen in Iranian (Saadat et al, 2001), Lebanese (Zgheib et al, 2013), Pakistani (Sohail et al, 2013), Taiwanese (Chang et al, 2006), Icelandic (Gudmundsdottir et al, 2001), Mexican (Rodriguez et al, 2014), and Caucasian and African-American (Van Emburgh et al, 2008) populations.…”

Section: Discussioncontrasting

confidence: 98%

“…The lack of association between GSTT1 null genotype and breast cancer has been seen in Dutch (van der Hel et al, 2004), Lebanese (Zgheib et al, 2013), Pakistani (Sohail et al, 2013), Icelandic (Gudmundsdottir et al, 2001), Mexican (Rodriguez et al, 2014), Caucasian and African-American (Van Emburgh et al, 2008) and Iranian (Hashemi et al, 2012) populations. Association of GSTT1 null genotype with breast cancer have been observed in studies from Northeast India (Kimi et al, 2016), Iowa (Zheng et al, 2002, Southern Taiwan (Chang et al, 2006), and China (Tang et al, 2015;Xiao et al, 2015;Song et al, 2016).…”

Section: Discussionmentioning

confidence: 94%

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GSTM1 and GSTT1 Genetic Polymorphisms and Breast Cancer Risk in Selected Filipino Cases

Kalacas

Garcia

Ortin

et al. 2019

Asian Pac J Cancer Prev

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Background:The association of genetic polymorphisms with cancer development has been shown to be race- and tumor site-specific. Thus, this study aimed to determine whether polymorphisms in the GSTM1 and GSTT1 genes are associated with breast cancer among selected Filipinos. Methods:A total of 136 histologically confirmed breast cancer cases were age- and sex-matched with 136 clinically healthy controls. Genomic DNA extracted from blood samples of participants were screened for GSTM1 and GSTT1 genetic polymorphisms by multiplex PCR. Results:The frequency of null genotypes among the cases (GSTM1: n=78; 57.4%; GSTT1: n=61; 44.9%) was not significantly different (p>0.05) from the controls (GSTM1: n=93; 68.4%; GSTT1: n=59; 43.4%). It was also demonstrated that risk for breast cancer was increased in passive smokers carrying the GSTM1 null (OR=2.56; 95% CI=1.38-4.75) or GSTT1 positive (OR=2.00; 95% CI=1.05-3.83) genotypes. Moreover, risk was decreased in alcohol users carrying the GSTT1 null (OR=0.39; 95% CI=0.16-0.97) genotype. Conclusion:This study suggests that variants of GSTM1 and GSTT1 may not be risk factors for breast cancer development among Filipinos. However, the risk may be increased when these genotypes were combined with lifestyle or environmental factors.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionmentioning

confidence: 94%

GSTM1 and GSTT1 Genetic Polymorphisms and Breast Cancer Risk in Selected Filipino Cases

Kalacas

Garcia

Ortin

et al. 2019

Asian Pac J Cancer Prev

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“…In contrast, an association between the GSTP1 polymorphisms and BC has been found to be exacerbated by alcohol consumption (44). Many factors can be considered for the inconsistent findings, such as population differences, ethnic origin, lifestyle habits, smoking, and alcohol consumption (45). Furthermore, other genetic variations might be associated with the risk of BC; for instance, hypermethylation of the GSTP1 promoter has been associated with BC risk (46,47).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms and Mutations in GSTP1, RAD51, XRCC1 and XRCC3 Genes in Breast Cancer Patients

et al. 2017

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Background Genotoxic factors, including ionizing radiation and oxidative stress, are associated with genomic instability and development of breast cancer (BC). The homologous recombination DNA repair (HRR) pathway, base excision repair (BER) mechanism, and antioxidative enzymes are required as defense mechanisms against these DNA damaging agents. GSTP1, XRCC1, XRCC3 and RAD51 proteins are essential components of antioxidation, BER and HRR of DNA, respectively. Deficiencies in BER, HRR and antioxidation pathways are involved in the progression of cancer. Methods Genomic DNA was extracted from formalin-fixed, paraffin-embedded tissue and blood samples of BC patients of an Italian population. Genomic DNA was also extracted from blood specimens of a control group. DNA sequencing was performed for six single-nucleotide polymorphisms (SNPs) in the GSTP1, RAD51, XRCC1 and XRCC3 genes in BC patients and the control group. Results Two variants in the 5′-UTR of the XRCC3 (rs1799794 A/G) and RAD51 (rs1801321) genes showed a significant association with susceptibility to BC (OR = 4.125; 95% CI 1.057-16.102; p = 0.03 and OR = 2.04; 95% CI 0.4925-8.449; p = 0.007, respectively). Additionally, we reported 2 mutations in intron 7 of the XRCC3 gene, CTdel (rs543072564) and A/G (rs369703243). Conclusions Our results underscored the existence of an association between XRCC3-5′-UTR-A/G (rs1799794) and RAD51-5′-UTR G172T (rs1801321) genotypes and BC risk in an Italian population. The presence of mutations in the intronic region of the XRCC3 gene highlights the importance of more sequence screening of DNA repair genes for possible genetic penetrance in BC.

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“…Previous studies have indicated that GSTP1 polymorphism is associated with various kinds of cancers, such as acute myeloid leukemia, lung cancer, breast cancer, colorectal cancer, brain tumor, and esophageal cancer (Cong et al, 2014;Silva et al, 2014;Song et al, 2014;Jaramillo-Rangel et al, 2015;Nasr et al, 2015;Sharma et al, 2015;Soto-Quintana et al, 2015;Zhou et al, 2015;Geng et al, 2016;Khabaz et al, 2016;Kimi et al, 2016). Several studies have also reported that GSTP1 polymorphism is associated with risk of gastric cancer in various populations, but the results were inconsistent (Nguyen et al, 2010;Zhang et al, 2011;Bao et al, 2012;García-González et al, 2012;Jing et al, 2012;Zhang et al, 2012;Ma et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

2017

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ABSTRACT. Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.

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Relevance of GSTM1, GSTT1 and GSTP1 Gene Polymorphism to Breast Cancer Susceptibility in Mizoram Population, Northeast India

Cited by 22 publications

References 12 publications

GSTM1 and GSTT1 Genetic Polymorphisms and Breast Cancer Risk in Selected Filipino Cases

GSTM1 and GSTT1 Genetic Polymorphisms and Breast Cancer Risk in Selected Filipino Cases

Polymorphisms and Mutations in GSTP1, RAD51, XRCC1 and XRCC3 Genes in Breast Cancer Patients

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

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