Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis

Gonçalves, Andréia Souza; Oliveira, Jéssica Petini; Oliveira, Carolina Ferrari Piloni de; Silva, Tarcı́lia Aparecida; Mendonça, Elismauro Francisco; Wastowski, Isabela Jubé; Batista, Aline Carvalho

doi:10.1016/j.humimm.2015.12.001

Cited by 22 publications

(11 citation statements)

References 38 publications

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“…It is a similarity between acute liver failure and severe sepsis shock and IL‐10 might contribute to immune paralysis. Recent reports showed that IL‐10 might impair major histocompatibility complex class II recycling and result in the reduction of major histocompatibility complex‐associated molecules, and in neutrophil dysfunction and immune paralysis, then lead to the rapid development of acute liver failure . In addition, Cox proportional hazards regression analyses showed MELD score, the presence of HE and plasma IL‐10 were independent risk factors for the mortality of AHCBLF patients.…”

Section: Discussionmentioning

confidence: 93%

Plasma interleukin‐10 predicts short‐term mortality of acute‐on‐chronic hepatitis B liver failure

Wang

Yong-sheng

et al. 2016

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 93%

Plasma interleukin‐10 predicts short‐term mortality of acute‐on‐chronic hepatitis B liver failure

Wang

Yong-sheng

et al. 2016

Aliment Pharmacol Ther

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“…We know that the interaction KIR-HLA has two sides of KIR and HLA. For example overexpression of HLA-E on surface of colorectal cancer cells can result in inhibition of NKs [53] and such patients have better survival from the disease [54]; of course the receptor of HLA-E is CD94/NKG2a [55], [56]. KIR2DL1 and 2DS1 interact with HLA-C2, and KIR2DL2, 2DL3 and 2DS2 interact with HLA-C1 [57]; so every mathematical predict do not occur.…”

Section: Resultsmentioning

confidence: 99%

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

et al. 2016

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Colorectal cancer is one of the most common types of inflammation-based cancers and is occurred due to growth and spread of cancer cells in colon and/or rectum. Previously genetic association of cell cycle genes, both proto-oncogenes and the tumor suppressors has been proved. But there were few studies about association of immune related genes such as killer-cell immunoglobulin-like receptors (KIRs). Thus we intend to perform a meta-analysis to find the association of different genes of KIR and susceptibility to be affected by colorectal cancer. The overall population of the four studies investigated in our meta-analysis was 953 individuals (470 individuals with colorectal cancer and 483 individuals in control groups). After the analyses, we concluded that colorectal cancer is affected by KIR2DS5 and also there were no protecting gene. This result shows the inflammatory basis of this cancer. In other words, in contrast to leukemia and blood cancers, colorectal cancers seem to be affected by hyper activity of natural killer-cells (NKs). Whys and therefore of this paradox, is suggested to be investigated further.

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“…Among the immune escape mechanisms used by tumor cells, HLA-G expression has been recently investigated in different types of human malignancies. 9,10,11,19 In the current literature, some studies have evaluated HLA-G immunoexpression in oral cancer. 6,11,19,21 However, to our knowledge, this is the first study to compare HLA-G expression in oral tongue and of the lower lip SCCs, tumors that knowingly have different behaviors and prognoses.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have associated a larger amount of Treg cells in malignant neoplasms with antitumor immune response evasion and, consequently, with a worse prognosis. 17,18 Investigations about the role of HLA-G in oral cancer microenvironment and its relationship with clinical parameters is still lacking in the literature 6,11,19 and, to date, there have been no investigations into the relationship between HLA-G and FoxP3+ Treg cells in these tumors. Therefore, the aim of the present study was to assess HLA-G expression in tumor cells and in FoxP3+ Treg cells in oral tongue and lower lip squamous cell carcinomas (SCCs), tumors with different behaviors and prognoses, and to verify its relationship with clinical parameters.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical evaluation of HLA-G and FoxP3+ T regulatory cells in oral cavity and lower lip squamous cell carcinomas

et al. 2019

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Human Leukocyte Antigen G (HLA-G) is a molecule involved in the tumor immunosuppression and also in the generation of regulatory T (Treg) cells, thus leading to evasion to the immune system host, and consequently, contributing to tumor progression in several cancers. The aim of this study was to evaluate the immunoexpression of HLA-G by tumor cells and FoxP3+ Treg cells in 25 oral tongue squamous cell carcinomas (SCCs) and 25 lower lip SCCs and analyze their relationship with clinical parameters. HLA-G expression was higher in oral tongue SCCs than in lower lip SCCs. In oral tongue SCCs and lower lip SCCs, no association between HLA-G expression and clinical parameters (tumor size, lymph node status, distant metastasis, and clinical stage) was verified (P>0.05). FoxP3+ Treg cells were detected along the tumor invasive front in all cases of oral tongue and lower lip SCCs. In oral tongue SCC cases, the number of Treg cells tended to be higher in smaller tumors, tumors without regional lymph node metastasis, and tumors in early clinical stages, but the difference was not statistically significant (P>0.05). A significant positive correlation was found between the expression of HLA-G by neoplastic cells and Treg cells in lower lip SCCs (p = 0.008). Our findings suggest the involvement of HLA-G and Treg cells in the modulation of immune responses in oral tongue and lower lip SCCs. This interaction between HLA-G and Treg cells may represent an evasion mechanism in these malignancies.

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Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis

Cited by 22 publications

References 38 publications

Plasma interleukin‐10 predicts short‐term mortality of acute‐on‐chronic hepatitis B liver failure

Plasma interleukin‐10 predicts short‐term mortality of acute‐on‐chronic hepatitis B liver failure

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

Immunohistochemical evaluation of HLA-G and FoxP3+ T regulatory cells in oral cavity and lower lip squamous cell carcinomas

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