Relevance of serum and salivary sialic acid in oral cancer diagnostics

Guruaribam, Victoria Devi; Sarumathi, T.

doi:10.4103/jcrt.jcrt_512_19

Cited by 12 publications

(8 citation statements)

References 19 publications

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“…Furthermore, this agent not only provides cytoprotection but also safeguards cell membranes ( 17 ). Multiple studies have established a correlation between elevated levels of SA and cancer, as evidenced in patients ( 18 ) with ovarian cancer ( 19 ), breast cancer ( 20 ), oral cancer ( 21 ), and neck cancer ( 22 ). Additionally, certain chemical agents have been shown to enhance disease invasion by altering SA levels or impeding SA production, as demonstrated in some studies ( 23 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer

Sun,

Tian,

Wang

et al. 2024

Front. Endocrinol.

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BackgroundRecently, serum sialic acid (SA) has emerged as a distinct prognostic marker for prostate cancer (PCa) and bone metastases, warranting differential treatment and prognosis for low-volume (LVD) and high-volume disease (HVD). In clinical settings, evaluating bone metastases can prove advantageous.ObjectivesWe aimed to establish the correlation between SA and both bone metastasis and HVD in newly diagnosed PCa patients.MethodsWe conducted a retrospective analysis of 1202 patients who received a new diagnosis of PCa between November 2014 and February 2021. We compared pretreatment SA levels across multiple groups and investigated the associations between SA levels and the clinical parameters of patients. Additionally, we compared the differences between HVD and LVD. We utilized several statistical methods, including the non-parametric Mann-Whitney U test, Spearman correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression.ResultsThe results indicate that SA may serve as a predictor of bone metastasis in patients with HVD. ROC curve analysis revealed a cut-off value of 56.15 mg/dL with an area under the curve of 0.767 (95% CI: 0.703-0.832, P < 0.001) for bone metastasis versus without bone metastasis and a cut-off value of 65.80 mg/dL with an area under the curve of 0.766 (95% CI: 0.644-0.888, P = 0.003) for HVD versus LVD. Notably, PCa patients with bone metastases exhibited significantly higher SA levels than those without bone metastases, and HVD patients had higher SA levels than LVD patients. In comparison to the non-metastatic and LVD cohorts, the cohort with HVD exhibited higher levels of alkaline phosphatase (AKP) (median, 122.00 U/L), fibrinogen (FIB) (median, 3.63 g/L), and prostate-specific antigen (PSA) (median, 215.70 ng/mL), as well as higher Gleason scores (> 7). Multivariate logistic regression analysis demonstrated that an SA level of > 56.15 mg/dL was independently associated with the presence of bone metastases in PCa patients (OR = 2.966, P = 0.018), while an SA level of > 65.80 mg/dL was independently associated with HVD (OR = 1.194, P = 0.048).ConclusionThe pretreatment serum SA level is positively correlated with the presence of bone metastases.

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Section: Introductionmentioning

confidence: 99%

Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer

Sun,

Tian,

Wang

et al. 2024

Front. Endocrinol.

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“…Such tumor markers can be utilized as diagnostic or prognostic markers for patients suffering from cancer. In order to decrease cancer morbidity and mortality cancer detection as early as possible is of great significance [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study”

Tarrad,

Hassan,

Shaker

et al. 2023

BMC Oral Health

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Background Early detection and diagnosis of malignant tumors is critical for improving the survival rate and treatment outcomes of oral cancer. Thus, the current prospective investigation was designed to verify the role, sensitivity, and specificity of salivary LINC00657 and miRNA-106a as diagnostic markers in oral squamous cell carcinoma patients as compared to oral lichen planus (as an example of oral potentially malignant disorders) and normal individuals, and to show LINC00657 relation to miR-106a. Methods A total of 36 participants were included, subdivided into 3 groups: Group I: 12 patients diagnosed with oral squamous cell carcinoma (OSCC). Group II: 12 patients diagnosed with oral lichen planus (OLP). Group III: 12 systemically free individuals with no oral mucosal lesions. Unstimulated salivary samples were collected from all participants to evaluate level of LINC00657 and miR-106a in different groups using quantitative real-time PCR. Results OSCC showed the highest LINC00657 and lowest miR-106a fold change among included groups. Receiver Operating Characteristic (ROC) curve analysis of the two biomarkers for detecting OSCC revealed that LINC00657 had higher diagnostic accuracy (DA) (83.3%) compared to miR-106a (80.4%). As for detecting OLP, ROC analysis showed that miR-106a had higher (DA) (61%) compared to LINC00657 (52.5%). To discriminate OSCC from OLP, the diagnostic accuracy of both markers is the same (75%). Moreover, differentiating OSCC grades II and III, ROC analysis showed that miR-106a had lower (DA) (60%) compared to LINC00657 (DA) (83.3%). Conclusions Salivary LINC00657 and miR-106a could be promising diagnostic markers for oral squamous cell carcinoma. Salivary LINC00657 may differentiate oral squamous cell carcinoma from oral potentially malignant disorders with considerable diagnostic accuracy. Moreover, low levels of salivary miR-106a could have the potential to indicate malignancy. Trial registration The study was retrospectively registered on clinicaltrial.gov with NCT05821179 (first trial registration in 26/3/2023), date of registration: 19/4/2023.

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“…β-galactoside α2,6-sialyltransferases could induce high HER2 α2,6-sialylation, which promoted the proliferation and invasion of tumor cells through protein kinase B (Akt) and ERK signaling pathways [ 76 ]. Meanwhile, with the aggravation of the disease, the content of SA was increased gradually, and the content of SA was decreased gradually during the remission period [ 77 , 78 ]. It may provide a novel approach to the diagnosis and therapeutic target of tumors.…”

Section: Biological Functions and Molecular Mechanisms Of Samentioning

confidence: 99%

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Li,

Lin,

Luo

et al. 2023

Foods

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Sialic acid (SA) is a kind of functional monosaccharide which exists widely in edible bird’s nest (EBN), milk, meat, mucous membrane surface, etc. SA is an important functional component in promoting brain development, anti-oxidation, anti-inflammation, anti-virus, anti-tumor and immune regulation. The intestinal mucosa covers the microbial community that has a significant impact on health. In the gut, SA can also regulate gut microbiota and metabolites, participating in different biological functions. The structure, source and physiological functions of SA were reviewed in this paper. The biological functions of SA through regulating key signaling pathways and target genes were discussed. In summary, SA can modulate gut microbiota and metabolites, which affect gene expressions and exert its biological activities. It is helpful to provide scientific reference for the further investigation of SA in the functional foods.

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Relevance of serum and salivary sialic acid in oral cancer diagnostics

Cited by 12 publications

References 19 publications

Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer

Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer

“Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study”

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

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