Relevance of the lectin pathway of complement in rheumatic diseases

Boldt, AB; Goeldner, Isabela; Ij, de Messias-Reason

doi:10.1016/b978-0-12-394317-0.00012-1

Cited by 24 publications

(21 citation statements)

References 280 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The activation cascade of the complement proteins is the rst-line defense barrier against Streptococcus pyogenes infections. As of their signi cant role in disposing of rheumatic etiological agents, the de ciency of lectin pathway molecules is considered as responsible for the seriousness and vulnerability to rheumatic morbidities [47,48]. The current writing about the role of MBL and colins in the pathogenesis of RF and RHD is as yet rare; however, their double function regarding RF has been hypothesized [11].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents Study

Gomaa

Khidr

Elshafei

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The innate immunity molecules against Streptococcus pyogenes infections include ficolin-3 that was thought to have a role in autoimmune diseases resulting from this infection such as rheumatic fever (RF) which goes on and leads to its most serious sequel, rheumatic heart disease (RHD). We aimed in this study to disclose if there is an association between ficolin-3 gene polymorphisms (rs4494157 and rs10794501) and RF with or without RHD for the first time in Egyptian adolescents. Methods: This study was carried out on 160 RF patients; eighty patients had RHD and eighty didn't have RHD. Besides, eighty ethnically and age-matched healthy subjects were selected as control. Ficolin-3 gene polymorphisms (rs4494157 and rs10794501) were genotyped by TaqMan® allelic discrimination assay. Serum ficolin-3 was quantitatively determined by ELISA. Results: Regarding ficolin-3 gene polymorphisms; no differences in the frequency of rs10794501 were found between the investigated groups, while polymorphism of rs4494157 showed a significant correlation between AA homozygous genotype, high serum ficolin-3, and RHD risk. Conclusion: Elevated serum ficolin-3 and carriage of AA genotype of rs4494157 appeared to be involved in RF and RHD pathogenesis and may be predictive tools for early recognition of RHD prone RF patients, and subsequent early prophylactic interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents Study

Gomaa

Khidr

Elshafei

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Low MASP-2 levels, for example, were associated with an increased risk of severe chemotherapy-induced neutropenia in children with cancer (Schlapbach et al, 2007) and an acute decrease of MASP-2 levels in the early phase of septic shock correlated with in-hospital mortality (Charchaflieh et al, 2012). In contrast, increased levels of innate immunity proteins, which can in part be explained by polymorphisms in the corresponding genes, may contribute to exaggerated inflammatory responses (Boldt et al, 2012). High postoperative levels of MASP-2, for example, were associated with poor prognosis in colorectal cancer patients (Ytting et al, 2008).…”

Section: Masps and Infectious Diseasesmentioning

confidence: 99%

MBL-associated serine proteases (MASPs) and infectious diseases

Beltrame

Boldt

Catarino

et al. 2015

Molecular Immunology

Self Cite

View full text Add to dashboard Cite

The lectin pathway of the complement system has a pivotal role in the defense against infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to carbohydrates or acetylated residues on pathogen surfaces, dimers of MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2) activate a proteolytic cascade, which culminates in the formation of the membrane attack complex and pathogen lysis. Alternative splicing of the pre-mRNA encoding MASP-1 results in two other products, MASP-3 and MAp44, which regulate activation of the cascade. A similar mechanism allows the gene encoding MASP-2 to produce the truncated MAp19 protein. Polymorphisms in MASP1 and MASP2 genes are associated with protein serum levels and functional activity. Since the first report of a MASP deficiency in 2003, deficiencies in lectin pathway proteins have been associated with recurrent infections and several polymorphisms were associated with the susceptibility or protection to infectious diseases. In this review, we summarize the findings on the role of MASP polymorphisms and serum levels in bacterial, viral and protozoan infectious diseases.

show abstract

“…Hallmark of RA is persistent symmetric polyarthritis resulting in muscle aches and pain. Anti-citrullinated protein antibodies (ACPA) produced by plasma cells during the preclinical phase of RA, stimulate osteoclast differentiation while, synovitis at the onset of disease leads to the production of cytokines, thus ensuing in bone erosion [15]. Antioxidants may protect cells by a variety of mechanisms, including the conversion of ROS to non-radical species (which are dependent on the antioxidant involved), breaking the auto-oxidative chain reaction initiated by ROS and decreasing localized oxygen concentrations [16,17].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-arthritic Potential of Casuarina equisetifolia Fruit Methanolic Extract

Vaidya¹,

Golwala²,

Shrimanker³

et al. 2020

EJMP

View full text Add to dashboard Cite

Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extract. Methodology: Extract was subjected to qualitative and quantitative investigation then antioxidant properties of extract was determine by two method namely Nitric Oxide free radical scavenging activity and Reducing power by FeCl 3 method. Based on Phytochemical and antioxidant result antiarthritic activity was performed on wistar rats using Complete Freund's Adjuvant (CFA) and evaluated different parameter like paw volume, arthritic index, biochemical parameter and hematological parameter. Results: In this study found that the methanolic extract of Casuarina equisetifolia fruit (MLCEF) contain significant percentage of secondary metabolite like poly phenol that properties was proved antioxidant activity. Antioxidant properties was determined by two methods the MLCEF IC50 Value 30.27±2.43 and 158.45±7.15 was found IC50 value reveled that MLCEF is a potent free radical Vaidya et al.; EJMP, 31(1): 42-53, 2020; Article no.EJMP.54842 43 scavenge capacity. Casuarina equisetifolia fruit (MLCEF) of 400 mg/kg, p.o. showed significant increasement in body wt from day 12 th to 21 st and significantly reduction in rat paw edema was observed from day 6 th to 21 st and it could be significantly normalize the haematological (like Hb, WBC and ESR) and biochemical abnormalities (like urea, ALT, AST and ALP) adjuvant induced arthritic rats in both developing and developed phases of CFA induced arthritis. Original Research Article Conclusion:The study outcome reveled that MLCEF is contain significant amount of polyphenol and that properties exhibit good antioxidant properties and significant antiarthritic properties. The actual mechanism of action of extracts on adjuvant induced arthritis is not clear with these studies. The action of extracts on proinflammatory mediators like TNF-α, Interleukins and other relevant mediators will be carried out in future to study its mechanism.

show abstract

Relevance of the lectin pathway of complement in rheumatic diseases

Cited by 24 publications

References 280 publications

The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents Study

The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents Study

MBL-associated serine proteases (MASPs) and infectious diseases

Antioxidant and Anti-arthritic Potential of Casuarina equisetifolia Fruit Methanolic Extract

Contact Info

Product

Resources

About