Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease

Ren, Yilong; Houghton, Peter J.; Hider, Robert C.

doi:10.1211/jpp.58.7.0015

Cited by 48 publications

(21 citation statements)

References 26 publications

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“…AChE activity was measured using a 96-well microplate reader (Ren et al, 2006;Mukherjee et al, 2007b) based on Ellman's method (Ellman et al, 1961). The enzyme hydrolyses the substrate acetylthiocholine resulting in the product thiocholine which reacts with Ellman's reagent (DTNB) to produce 2-nitrobenzoate-5-mercaptothiocholine and 5-thio-2-nitrobenzoate which can be detected at 405 nm.…”

Section: Chemicals Acetylthiocholine Iodide (Atci) Acetylcholinestementioning

confidence: 99%

Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity

Mukherjee

Venkatesan

Houghton

2007

Phytotherapy Research

185

107

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The cholinergic hypothesis of Alzheimer's disease (AD) has provided the rationale for the current pharmaco-therapy of this disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for potent and long-acting acetylcholinesterase (AChE) inhibitors that exert minimal side effects in AD patients is still ongoing. AChE inhibitors are currently the only approved therapy for the treatment of Alzheimer's disease; only a limited number of drugs are commercially available. Hydroalcohol extracts of six herbs, Andrographis paniculata, Centella asiatica, Evalvulus alsinoides, Nardostachys jatamansi, Nelumbo nucifera, Myristica fragrans used in Indian systems of medicine, were tested for in vitro acetylcholinesterase inhibitory activity based on Ellman's method in 96-well microplates using AChE obtained from bovine erythrocytes. The results showed that the hydroalcohol extract from Centella asiatica, Nardostachys jatamansi, Myristica fragrans, Evalvulus alsinoides inhibited 50% of AChE activity at concentrations of 100-150 microg/mL. Andrographis paniculata and Nelumbo nucifera extracts showed a weak inhibition of acetylcholinesterase with IC(50) values of 222.41 +/- 19.87 microg/mL and 185.55 +/- 21.24 microg/mL, respectively. Physostigmine was used as a standard and showed inhibition of acetylcholinesterase with an IC(50) value of 0.076 +/- 0.0042 microg/mL.

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Section: Chemicals Acetylthiocholine Iodide (Atci) Acetylcholinestementioning

confidence: 99%

Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity

Mukherjee

Venkatesan

Houghton

2007

Phytotherapy Research

185

107

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“…In an effort to evaluate the bioactive potential of the leaf extract of Cynometra couliflora L., in different solvents using Ellman's calorimetric method in a 96 well plate, Ado, Abas [61] demonstrated that although ethyl acetate fraction exhibit better potency against AChE. Generally, extracts from the more polar fractions of methanol, ethyl acetate, n-butanol and aqueous soluble fractions showed a remarkable anti AChE activity as against the corresponding hexane and dichloromethane fractions, with IC 50 values of 0.065 ± 0.008, 0031 ± 0.012, 0.11 ± 0.005 and 0.052 ± 0.015 mg/ml respectively.…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

Usman¹

2017

JDMP

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Abstract:Alzheimer's disease (AD) is a slow and progressive neurodegenerative disease, leading to a breakdown in memory preservation and absence of cognitive reasoning and language skills. It is the most popular neurodegenerative disease worldwide, with nearly 20 million new incidences recorded every year. The enzymes, acetyl cholinesterase (AChE) and butyryl-cholinesterase (BChE) play important roles in the cholinergic deficit through enhanced degradation of the neurotransmitter, acetylcholine (ACh). In most cases, to improve neurotransmission and to alleviate cholinergic deficit, the focus is mainly on acetyl cholinesterase (AChE) and butyl cholinesterase (BCh). Currently, drugs for the treatment of AD (Rivastigmine, galanthamine, donepezil and Memantine) targets the later stages and implicated in the progression of the disease. Acetyl cholinesterase enzyme (AChE) is especially an attractive target for the rational drug design and for the discovery of mechanism based inhibitors; this is because of its role in the hydrolysis of neurotransmitter, acetylcholine. Many plants serve as potential source of AChE and BChE inhibitors, and useful compounds that could provide templates for the development of drugs for the treatment of AD. This paper provides a review of several medicinal plants tested for anti-AChE and or BChE, many of which contains promising bioactive compounds as potential anti-cholinesterase that could serve as candidates for the development of drugs to treat AD.

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“…[159] reported that PUFAs have a relatively moderate effect on AChE, DHA being the strongest inhibitor. The authors suggested that long-chain PUFAs possess specific molecular features responsible for this promising activity [159]. Andrade et al .…”

Section: Neuroprotective Compounds From Macroalgaementioning

confidence: 99%

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

2014

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Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.

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Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease

Cited by 48 publications

References 26 publications

Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity

Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

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