One of the most important tools for improving the OHS level in process industries is represented by risk analysis and assessment. Within industrial units in operation or in the ones which find themselves in the design phase, risk assessment is carried out for determining the hazards which may occur and which may lead to unwanted events, such as hazardous toxic releases, fires and explosions. Accidental releases of toxic/flammable/explosive substances may have serious consequences on workers or on the neighbouring population, therefore the need to establish safety areas based on best practices in the field and on scientific grounds is fully justified. Pressure tanks containing hazardous materials represent one of the most relevant industrial facilities within process plants, being most of the time exposed to hazardous toxic releases, fire and explosion risks. The current study aims to evaluate the consequences and discuss the safety distances required in case of an accidental release of a hazardous material from a tank located within a process plant, using process analysis software tools. Accident scenarios are modelled for comparison purposes with consequence modelling software widely used in safety engineering.