Reliability and validity of Amharic version of EORTC QLQ-C30 and QLQ-BR23 modules for assessing health-related quality of life among breast cancer patients in Ethiopia

Alemayehu, Diriba; Gebremariam, Esayas Tadesse; Ali, Getnet Yimer

doi:10.1186/s12955-019-1257-z

Cited by 16 publications

(22 citation statements)

References 19 publications

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“…The most obvious scaling failure was observed for the systematic therapy side effect. This might have occurred because systematic therapy side effects are often nonspeci c. This is in contrast to a previous study performed on breast cancer patients [10].…”

Section: Discussioncontrasting

confidence: 58%

“…The breast symptom and arm symptom scales also had strong correlations with the pain scale of the QLQ-C30. A similar study performed in Turkey showed strong correlations between the symptom scales of QLQ-BR23 and QLQ-C30 [10,31]. This might be explained by the two dimensions being conceptually related.…”

Section: Modi Cation and Model Tmentioning

confidence: 84%

“…The nal version of the EORTC QLQ-BR45 is currently available for use in clinical trials and practice, and it has been translated into 19 different languages [9]. The original QLQ-BR23 was validated in Ethiopia 21 years after its original development [10]. Since its original development, there have been many advances in the diagnosis and treatment of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Translation and Validation of The EORTC QLQ-BR45 Among Ethiopian Breast Cancer Patients

Getu¹,

Wang²,

Kantelhardt³

et al. 2021

Preprint

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Objective This study aimed to examine the validity and reliability of the EORTC QLQ-BR45 questionnaire.Methods This study included 248 breast cancer patients who completed the QLQ-BR45 and QLQ-C30 questionnaires. The internal reliability, test-retest reliability, and the content, concurrent, convergent, divergent, and clinical validity of the tool were examined. The statistical analyses included Cronbach’s α coefficient, Pearson’s correlation coefficient, standardised response mean residual (SRMR), comparative fit index (CFI), t-test, and root mean square error of approximation (RMSEA). Result All items were marked as relevant, and item-level content validity index (I-CVI) scores ranged from 0.83 to 1. The Cronbach’s α coefficient was 0.80 for all domains. All subscales met the minimal standards of reliability except the arm symptom scale (0.66). The test-retest reliability coefficient was 0.77 for all domains. Seven out of the 12 hypothesised scales showed positive correlations (r > 0.40) between the QLQ-BR45 and QLQ-C30 scales. Multitrait scaling analysis showed that the item-scale correlations exceeded the 0.40 criterion for item-convergent validity for 11 of the 12 hypothesised scales. The correlation coefficients between an item and its own subscale were significantly higher than with other subscales.Conclusion The EORTC QLQ-BR45 had good reliability and validity, and it can be used to measure the quality of life of breast cancer patients in Ethiopia.

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Section: Discussioncontrasting

confidence: 58%

Section: Modi Cation and Model Tmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Translation and Validation of The EORTC QLQ-BR45 Among Ethiopian Breast Cancer Patients

Getu¹,

Wang²,

Kantelhardt³

et al. 2021

Preprint

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“…The cognitive function scale displayed a Cronbach's alpha of 0.50 for the English version and of 0.66 for the Luganda version. A low alpha coefficient for the cognitive scale has been reported in other studies in East Africa [7,12,30]. It has been argued that this may to some extent be due to the small number of items in the scale.…”

Section: Discussionmentioning

confidence: 81%

“…The questionnaire is applicable in more than 70 countries worldwide including the major languages spoken in the Western world and Asia [9]. In Sub-Saharan Africa, the questionnaire is available in 9 languages: Afrikaans, Amharic, Ilokano, Kiswahili, Sepedi, Sotho, Xhosa, Yoruba and Zulu [9][10][11][12]. In Uganda no valid and reliable instrument for assessment of generic HRQoL in adults with cancer exists.…”

mentioning

confidence: 99%

Psychometric properties of the EORTC QLQ-C30 in Uganda

Naamala

Orem

Nalwadda

et al. 2021

Health Qual Life Outcomes

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Background Self-reported measures play a crucial role in research, clinical practice and health assessment. Instruments used to assess self-reported health-related quality of life (HRQoL) need validation to ensure that they measure what they are intended to, detect true changes over time and differentiate between subjects. A generic instrument measuring HRQoL adapted for use among people living with cancer in Uganda is lacking; therefore, this study aimed to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 in patients with cancer in Uganda. Methods Adult patients with various types of cancer (n = 385) cared for at the Uganda Cancer Institute answered the EORTC QLQ-C30 in Luganda or English language, the two most spoken languages in the country. The two language versions were evaluated with regard to data quality (floor and ceiling effects and missing responses), reliability (internal consistency) and validity (construct, known-group and criterion). Construct validity was examined through confirmatory factor analysis (CFA). Mean scores were compared between groups differing in disease stage to assess known-group validity. Criterion validity was examined according to associations between two QLQ-C30 subscales (Global quality of life and Physical function) and the Karnofsky Performance Scale (KPS). Results Floor and ceiling effects were observed for several scales in the Luganda and English versions. All EORTC scales with the exception of Cognitive function (Luganda α = 0.66, English α = 0.50) had acceptable Cronbach’s alpha values (0.79–0.96). The CFA yielded good fit indices for both versions (RMSEA = 0.08, SRMR = 0.05 and CFI = 0.93). Known-group validity was demonstrated with statistically significant better HRQoL reported by patients with disease stages I–II compared to those in stages III–IV. Criterion validity was supported by positive correlations between KPS and the subscales Physical function (Luganda r = 0.75, English r = 0.76) and Global quality of life (Luganda r = 0.59, English r = 0.72). Conclusion The Luganda and English versions of the EORTC QLQ-C30 appear to be valid and reliable measures and can be recommended for use in clinical research to assess HRQoL in adult Ugandans with cancer. However, the cognitive scale did not reach acceptable internal consistency and needs further evaluation.

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Psychometric properties of the Spanish version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30)

et al. 2021

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Purpose The aim of this study was to analyze the internal structure of the EORTC QLQ-C30, to examine the validity and normative data for cancer patients. Method Exploratory and Confirmatory factor analyses were conducted to explore the scale’s dimensionality and test for strong measurement invariance across sex and tumor site. All the analyses were based on a multicenter cohort of 931 patients who completed the Brief Symptom Inventory (BSI-18) and the EORTC QLQ-C30. Results Our findings indicate that the EORTC QLQ-C30 has acceptable psychometric properties and an internal structure that is well accounted for a bifactor model: a general factor that evaluates quality of life and a group factor that would analyze physical health that would be defined by physical function, role function, and fatigue. The result of the multi-group CFA revealed a strong invariance according to sex, tumor, and over time. Reliability of the EORTC exceeding 0.86 and the simple sum of the items of the scale was a good indicator of oncology patients’ quality of life. Both factors correlate closely with depression, anxiety, and psychological distress and are sensitive to change, especially the quality of life, with a significant decrease in the post-test. Conclusion The Spanish version of the EORTC QLQ-C30 proved to be a valid, reliable instrument to appraise quality of life in cancer patients. The normative data collected from this study may be useful for the early detection of initial symptoms of deterioration of quality of life in oncology patients.

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Reliability and validity of Amharic version of EORTC QLQ-C30 and QLQ-BR23 modules for assessing health-related quality of life among breast cancer patients in Ethiopia

Cited by 16 publications

References 19 publications

Translation and Validation of The EORTC QLQ-BR45 Among Ethiopian Breast Cancer Patients

Translation and Validation of The EORTC QLQ-BR45 Among Ethiopian Breast Cancer Patients

Psychometric properties of the EORTC QLQ-C30 in Uganda

Psychometric properties of the Spanish version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30)

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