Objective: Disease outbreak not only carries the risk of death to the public due to the infection, it also endures an unbearable psychological impact on the mental health of the individuals. This study aims to explore and evaluate the burden of psychological problems on the Iranian general population during the outbreak of COVID-19.Method: A cross-sectional web-based survey was conducted among the general population of Iran age 15 and above. Demographic variables, depression, and anxiety symptoms were evaluated using the Patient Health Questionnaire-9 and General Anxiety Disorder-7 questionnaires.Results: Among the 8591 participants, the mean age was 34.37 (±11.25) years and 66.4% were female while 33.6% were male. Based on our results, 1295 (15.07%) and 1733 (20.17%) of the general population had depression and anxiety respectively. Based on the demographic variables, Among the risk factors for both anxiety and depression, one could name female gender, whereas getting information about the disease from medical journals and articles, being older and being married were considered as protective factors. In terms of depression, being a non-healthcare worker was a risk factor. On the other hand, for anxiety, having higher education was a protective factor while a higher number of individuals in a household was considered as a risk factor.Conclusions: This study identified a major mental health problem in the Iranian population during the time of the COVID-19 outbreak. Therefore, establishing a targeted mental health support program during the time of public emergencies, such as the disease outbreak, is advised.