Reliability of Calf Bioelectrical Impedance Spectroscopy and Magnetic-Resonance-Imaging-Acquired Skeletal Muscle Hydration Measures in Healthy People

Sawant, Anuradha; House, Andrew A.; Chesworth, Bert M.; Gati, Joseph S.; Lindsay, Robert M.; Connelly, Denise M.; Bartha, Robert; Overend, Tom J.

doi:10.1155/2013/563494

Cited by 3 publications

(5 citation statements)

References 48 publications

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“…One of the main objectives of HD is to reduce excess ECF volume (1,5,17,22). Thus, the extent and location where those decreases occur can be quantified with MRI or, more economically, with a portable NMR sensor assuming that ECF volume scales with RA long and RA b , respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Nuclear magnetic resonance (NMR) relaxometry, on the other hand, provides a direct, noninvasive measurement of fluid volume and its environment (21). Quantitative magnetic resonance imaging (MRI) relaxometry is more reliable than BI when measuring muscle hydration; however, it is impractical for routine use because MRI has limited availability and is restricted to use within the scanner suite (22). Portable NMR sensors can perform the same quantitative measurements as MRI scanners while also being convenient for routine use.…”

Section: Introductionmentioning

confidence: 99%

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Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

Colucci

Corapi

et al. 2019

Sci. Transl. Med.

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Magnetic resonance imaging (MRI) is a powerful diagnostic tool, but its use is restricted to the scanner suite. Here, we demonstrate that a bedside nuclear magnetic resonance (NMR) sensor can assess fluid status changes in individuals at a fraction of the time and cost compared to MRI. Our study recruited patients with end-stage renal disease (ESRD) who were regularly receiving hemodialysis treatments with intradialytic fluid removal as a model of volume overload and healthy controls as a model of euvolemia. Quantitative T2 measurements of the lower leg of patients with ESRD immediately before and after dialysis were compared to those of euvolemic healthy controls using both a 0.28-T bedside single-voxel NMR sensor and a 1.5-T clinical MRI scanner. In the MRI data, we found that the first sign of fluid overload was an expanded muscle extracellular fluid (ECF) space, a finding undetectable at this stage using physical exam. A decrease in muscle ECF upon fluid removal was similarly detectable with both the bedside sensor and MRI. Bioimpedance measurements performed comparably to the bedside NMR sensor but were generally worse than MRI. These findings suggest that bedside NMR may be a useful method to identify fluid overload early in patients with ESRD and potentially other hypervolemic patient populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

Colucci

Corapi

et al. 2019

Sci. Transl. Med.

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“…Measurement bias at higher values of ratio of ECF and ICF may also have contributed to poor associations prior to HD treatment (Sawant et al. ). This supports our findings of nonsignificant associations between the measures of individual skeletal muscle hydration obtained using MRI and BIS, before HD in participants with ESRD.…”

Section: Discussionmentioning

confidence: 99%

“…Our earlier investigations in healthy populations have established that the reliability of T 2 is excellent (ICC 2,1 : 0.9) whereas the same for ADC is poor to moderate (ICC 2,1: 0.6) (Sawant et al. ). Hence we chose to investigate the association between calf BIS (cBIS) measures and T 2 for the purposes of this study.…”

Section: Introductionmentioning

confidence: 92%

Association between muscle hydration measures acquired using bioelectrical impedance spectroscopy and magnetic resonance imaging in healthy and hemodialysis population

et al. 2015

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Establishing the effect of fluctuating extracellular fluid (ECF) volume on muscle strength in people with end‐stage renal disease (ESRD) on hemodialysis (HD) is essential, as inadequate hydration of the skeletal muscles impacts its strength and endurance. Bioelectrical impedance spectroscopy (BIS) has been a widely used method for estimating ECF volume of a limb or calf segment. Magnetic resonance imaging (MRI)‐acquired transverse relaxation times (T2) has also been used for estimating ECF volumes of individual skeletal muscles. The purpose of this study was to determine the association between T2 (gold standard) of tibialis anterior (TA), medial (MG), and lateral gastrocnemius (LG), and soleus muscles and calf BIS ECF, in healthy and in people with ESRD/HD. Calf BIS and MRI measures were collected on two occasions before and after HD session in people with ESRD/HD and on a single occasion for the healthy participants. Linear regression analysis was used to establish the association between these measures. Thirty‐two healthy and 22 participants on HD were recruited. The association between T2 of TA, LG, MG, and soleus muscles and ratio of calf BIS‐acquired ECF and intracellular fluids (ICF) were: TA: β = 0.30, P > 0.05; LG: β = 0.37, P = 0.035; MG: β = 0.43, P = 0.014; soleus: β = 0.60, P < 0.001. For the HD group, calf ECF was significantly associated with T2 of TA (β = 0.44, P = 0.042), and medial gastrocnemius (β = 0.47, P = 0.027) following HD only. Hence BIS‐acquired measures cannot be used to measure ECF volumes of a single muscle in the ESRD/HD population; however, BIS could be utilized to estimate ratio of ECF: ICF in healthy population for the LG, MG, and soleus muscles.

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“…Both sets of equations appear to over-estimate muscle mass compared to MFBIA and MRI, with increasing bias with increasing muscle. All imaging techniques will overestimate muscle mass when patients are volume overloaded, due to the increased water content of muscle [10].…”

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confidence: 99%

Comparison of multifrequency bioimpedance measured lean mass to that calculated from anthropomometric measurements in patients with chronic kidney disease

Maharjan

Jiang²,

Slee³

et al. 2019

Eur J Clin Nutr

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Patients with chronic kidney disease (CKD) are at increased risk of sarcopenia. Previous studies have proposed equations to estimate muscle mass based on triceps skin fold thickness and mid upper arm circumference, with or without adjustment for hand grip strength (HGS). We wished to evaluate their usefulness compared to multifrequency segmental bioimpedance (MFBIA) measured appendicular lean mass (ALM). We audited 160 CKD patients attending outpatient clinics, 65.6% male, median age 73 (62-81.5) years. We calculated muscle mass using six proposed equations based on anthropometric measurements. These equations over estimated muscle mass compared to MFBIA with a mean bias ranging from 3.4 to 35.9 kg. Apart from one equation, there was a systematic bias, with bias increasing with increasing fat mass (ranging from r= 0.17, p=0.044 to r=0.65, p<0.001). For CKD patients we found that most of the previously proposed equations based on anthropometric equations overestimated muscle mass compared to MFBIA. Body Patients with chronic kidney disease (CKD) are at increased risk of muscle loss due to multiple factors, including dietary restrictions, metabolic acidosis, inflammation, urinary protein losses and vitamin D deficiency [1]. Pathological loss of muscle mass, termed sarcopenia is associated with increased

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Reliability of Calf Bioelectrical Impedance Spectroscopy and Magnetic-Resonance-Imaging-Acquired Skeletal Muscle Hydration Measures in Healthy People

Cited by 3 publications

References 48 publications

Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

Association between muscle hydration measures acquired using bioelectrical impedance spectroscopy and magnetic resonance imaging in healthy and hemodialysis population

Comparison of multifrequency bioimpedance measured lean mass to that calculated from anthropomometric measurements in patients with chronic kidney disease

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