Fluorescence-based intraoral cameras are increasingly gaining more interest in the modern dental practice, as an aid for the early detection of carious lesions. Such devices can have different operating systems, such as infrared lasers, quantitative light fluorescence (QLF), or LED lights, but they all rely on the fluorescent properties of tooth structures. Healthy enamel and enamel affected by demineralization have different light-scattering properties, a fact that allows for distinction under excitation with light of a known wavelength. The central problem in the treatment of dental decay is that operational care is still considered the predominant management plan for caries control in the general practice. Devices that use fluorescence have the potential to improve the detection and management of carious lesions significantly. Currently, there are several intraoral devices that employ fluorescence on the market, but more validation studies would be required to uphold the interest of the newly developed devices and to justify their reliability in clinical practice. Dental professionals cannot yet solely rely on one single-fluorescence device for incipient caries diagnosis, but they already present themselves as useful adjunctive tools to traditional examination methods.