Reliability of MRI-Derived Depth of Invasion of Oral Tongue Cancer

Murakami, Ryuji; Shiraishi, Shinya; Yoshida, Ryoji; Sakata, Junki; Yamana, K.; Hirosue, Akiyuki; Uchiyama, Yoshikazu; Nakayama, Hideki; Yamashita, Yasuyuki

doi:10.1016/j.acra.2018.08.021

Cited by 53 publications

(53 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a signi cant contrast between the Finnish and Saudi-Arabian biopsies in relation to detecting the invasive front with far more of invasive front observed in the Finnish samples. The value of imaging methods in evaluating the DOI has been reported, although it is possible to overestimate it by as much as 3 mm when compared with histopathological assessment [19,20]. A combination of clinical estimation and preoperative imaging evaluation of DOI, supplemented by further biopsy evaluation will greatly increase the accuracy of the tumor staging.…”

Section: Discussionmentioning

confidence: 99%

Biopsy Quality is Essential for Preoperative Prognostication in Oral Tongue Cancer

Bello

Wennerstrand

Suleymanova

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: A role for incisional biopsy in preoperative prognostication is increasingly being advocated in oral tongue squamous cell carcinomas (OTSCC). Biopsies at two locations were compared and prognostic factors in biopsies and their corresponding resections were evaluated. Methods: A total of 138 OTSCC biopsy slides from Finland and Saudi-Arabia were compared for size (horizontal and vertical) and invasive front. The Finnish cases were assessed for tumor stroma ratio (TSR) and tumor-infiltrating lymphocytes (TILs) using light microscopy and digital image analysis assessment and compared. Furthermore, TSR, TILs, and previously analyzed budding and depth of invasion (BD) score in biopsies were compared with their evaluation in the corresponding resections. Results: Finnish biopsies were deeper than Saudi-Arabian biopsies (59% versus 42%) while Saudi-Arabian biopsies were wider (98% versus 76%). Invasion fronts were more readily assessable in Finnish biopsies (72% versus 40%). There was 86.8% agreement between TSR and 75% agreement between TIL evaluation using light microscopy and digital assessment. Significant agreement was obtained on comparing the TSR (P=0.04) and BD (P<0.001) values in biopsies and resections. Conclusions: Biopsies of ≥5 mm depth from representative OTSCC areas are essential for prognostic information. Clinical pathologists are advised to assess BD score and TSR for prognostic features in such biopsies.

show abstract

Section: Discussionmentioning

confidence: 99%

Biopsy Quality is Essential for Preoperative Prognostication in Oral Tongue Cancer

Bello

Wennerstrand

Suleymanova

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…MRI-determined DOI was measured based on T1-weigthed layers by a 1.5T scan [13,14], it was defined as the vertical distance between the deepest point of tumor infiltration and the simulated normal mucosal junction ( Figure 1). For exogenous tumors, the part above the mucosal surface was neglected, and for ulcerative tumors, the invaginated part was added [17].…”

Section: Methodsmentioning

confidence: 99%

“…Depth of invasion (DOI) is now added in the newest edition of AJCC tumor-node-metastasis staging system [9], and abundant literature has showed the significant relationship between DOI and neck lymph node metastasis [10][11][12], however, data regarding pathologic DOI usually can not be obtained by frozen section or incisional biopsy, it might has limited role on benefiting decision making of neck treatment preoperatively. MRI has been widely used to evaluate the soft tissue disease, and current evidence has reported the reliability of MRI in measuring the DOI [13,14] as well as the prognostic value of MRI-determined tumor thickness in tongue SCC [15,16], the MRI-determined DOI is significantly different from the MRI-determined tumor thickness, but whether MRI-determined DOI has the same effect with the MRI-determined tumor thickness and whether it could be used as an indicator for END for cT1N0 tongue SCC remain unknown, therefore, the main goal of current study was to clarify these questions.…”

mentioning

confidence: 99%

Depth of invasion determined by MRI in cT1N0 tongue: is it an indicator for elective neck dissection?

Yuan

Kang

et al. 2019

Preprint

View full text Add to dashboard Cite

Abstracts Background Depth of invasion (DOI) could be calculated by MRI preoperatively, whether MRI-determined DOI could predict the prognosis and whether it could be used as an indicator for neck dissection for cT1N0 tongue squamous cell carcinoma (SCC) remain unknown, the main goal of the current study aimed to answer the questions. Methods Patients with surgically treated cT1N0 tongue SCC were retrospectively enrolled, MRI-determined DOI was measured based on T1-weigthed layers by a 1.5T scan. A multivariate logistic regression analysis model was used to determine the independent predictors for occult neck lymph node metastasis. The main study endpoints were locoregional control survival (LRC) and disease specific survival (DSS), the Cox model was used to determine the independent prognostic factors for the LRC and DSS. Results Occult neck lymph node metastasis was noted in 26 (17.2%) patients, ROC curve indicated the optimal cutoff value of MRI-determined DOI was 7.5mm for predicting neck lymph node metastasis with sensitivity of 86.9%. The factors of lymphovascular invasion, MRI-determined DOI, pathologic DOI, and pathologic tumor grade were significantly associated with the presence of neck lymph node metastasis in univariate analysis, further logistic regression analysis confirmed the independence of lymphovascular invasion, MRI-determined DOI, and pathologic DOI in predicting the neck lymph node metastasis. The 5-year LRC and DSS rates were 84% and 90%, respectively. Cox model analysis suggested the MRI-determined DOI was an independent prognostic factor for both the LRC and DSS. Conclusions Elective neck dissection is suggested if MRI-determined DOI is greater than 7.5mm in cT1N0 tongue SCC, and MRI-determined DOI ≥7.5mm indicates more risk for disease recurrence and cancer caused death.

show abstract

“…There are severalimaging methods available for preoperative evaluation.More recent studies suggest that the high resolution of magnetic resonance imaging (MRI) is reliable optimally depicts soft tissue tumor extension, and is useful to assess tumor thickness in predicting cervical lymph node metastasis [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Multiparametric Mri-based Nomogram for Predicting Occult Metastasis Risk in Early Tongue Squamous Cell Carcinoma

Saenthaveesuk

Yang

Zeng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Nomograms are currently used in predicting individualized outcomes in clinical oncology of several cancers. However, nomograms for evaluating occult nodal metastasis of patients with squamous cell carcinoma of lateral tongue (SCCLT) have not been widely investigated for their functionality. This retrospective cohort study was designed to address this question.Methods: This study was divided into primary and validation cohorts. The primary cohort comprised 120 patients diagnosed between 2012 and 2017, whereas the validation cohort included 41 patients diagnosed thereafter. The diagnostic value of multiparametric MRI, including radiologic tumor thickness threshold (rTTT) in three-dimensions, paralingual distance, and sublingual distance were investigated. A nomogram was developed based on stepwise logistic regression of potential predictors associated with nodal metastasis in the primary cohort and then tested for predictive accuracy in the validation cohort using area under the curve (AUC) and goodness-of-fit tests.Results: Multivariate analysis, tumor size (odd ratio [OR] 15.175, 95% confidence interval [CI] 1.436-160.329, P = 0.024), rTTT (OR 11.528, 95% CI 2.483-53.530, P = 0.002), paralingual distance (OR 11.976, 95% CI 1.981-72.413, P = 0.005), and tumor location (OR 6.311, 95% CI 1.514-26.304, P = 0.011) were included in the nomogram to predict the likelihood of having cervical metastasis. A nomogram cutoff value of 210 points (sensitivity 93.8%, specificity 87.5%) was significantly different to classify the patients metastasis risk group (P< 0.001). Nomogram showed predictive accuracy with AUC 0.881 (95% CI 0.779–0.983, P< 0.001) and good calibration after the validation.Conclusions: A preoperative nomogram incorporating multiparametric MRI demonstrated good prediction and performed adequately in our study. Three-dimensional assessment of occult metastasis risk value obtained from this nomogram can assist in preoperative decision making whether to manage with neck surgery for individual patients with early-stage SCCLT. The probability of nodal metastasis tended to be greater than 20% in patients with high metastasis risk or nomogram total score > 210 points.

show abstract

Reliability of MRI-Derived Depth of Invasion of Oral Tongue Cancer

Cited by 53 publications

References 18 publications

Biopsy Quality is Essential for Preoperative Prognostication in Oral Tongue Cancer

Biopsy Quality is Essential for Preoperative Prognostication in Oral Tongue Cancer

Depth of invasion determined by MRI in cT1N0 tongue: is it an indicator for elective neck dissection?

Development and Validation of Multiparametric Mri-based Nomogram for Predicting Occult Metastasis Risk in Early Tongue Squamous Cell Carcinoma

Contact Info

Product

Resources

About