Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study

Palleschi, Simonetta; Angelis, Sandro De; Diana, Loretta; Rossi, Barbara; Papa, Vincenza; Severini, Giancarlo; Splendiani, G

doi:10.1515/cclm.2007.266

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…Some authors skeptically refer to MDA weight as an oxidative stress marker [27] ; however, our results ( fig. 1 a) are in line with a previous study postulating an association between MDA levels and prevalent cardiovascular disease [28] , and confirm the significance of these biomarkers in uremic patients.…”

Section: Discussioncontrasting

confidence: 70%

Estimation of Oxidative Stress Markers in Chronic Kidney Disease

Kuchta¹,

Pacanis²,

Kortas-Stempak³

et al. 2010

Kidney Blood Press Res

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Changes mediated by oxidative stress are thought to be involved with atherosclerosis in patients with chronic kidney disease (CKD). The purpose of this study was to analyze the markers of oxidative damage and the activity of antioxidative enzymes as well as the total antioxidant capability in patients with different stages of CKD, both conventionally treated and dialyzed. We evaluated the oxidative modification of lipids (by oxidized low-density lipoprotein and malonodialdehyde levels) and proteins (by advanced oxidation protein products level). We also assessed the activity of paraoxonase-1 and glutathione peroxidases and total antioxidant status. Compared with the control group, the uremic patients, both dialyzed and nondialyzed, had higher levels of all studied plasma oxidative stress markers and decreased activity of antioxidative enzymes. Our results lead us to conclude that oxidative stress seems to be related rather to the uremic state than to the dialysis treatment. We also showed that estimating total antioxidant status in a simple test is unreliable for assessing the antioxidant ability of patients with CKD.

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Section: Discussioncontrasting

confidence: 70%

Estimation of Oxidative Stress Markers in Chronic Kidney Disease

Kuchta¹,

Pacanis²,

Kortas-Stempak³

et al. 2010

Kidney Blood Press Res

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“…Our data suggest that 8-OHdG can be used as a reliable biomarker of oxidative DNA damage in chronic stroke patients. Studies claiming the reliability of 8-OHdG as a biomarker in stroke rehabilitation are still limited; however, the reliability of other biomarkers of oxidative stress have been validated in human samples under different pathologic conditions [18,19]. This study selected subjects, who were chronic stroke patients (onset time > 6 months) and medically stable.…”

Section: Discussionmentioning

confidence: 99%

The Reliability and Predictive Ability of a Biomarker of Oxidative DNA Damage on Functional Outcomes after Stroke Rehabilitation

Hsieh

Lin

Korivi

et al. 2014

IJMS

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We evaluated the reliability of 8-hydroxy-2′-deoxyguanosine (8-OHdG), and determined its ability to predict functional outcomes in stroke survivors. The rehabilitation effect on 8-OHdG and functional outcomes were also assessed. Sixty-one stroke patients received a 4-week rehabilitation. Urinary 8-OHdG levels were determined by liquid chromatography–tandem mass spectrometry. The test-retest reliability of 8-OHdG was good (interclass correlation coefficient = 0.76). Upper-limb motor function and muscle power determined by the Fugl-Meyer Assessment (FMA) and Medical Research Council (MRC) scales before rehabilitation showed significant negative correlation with 8-OHdG (r = −0.38, r = −0.30; p < 0.05). After rehabilitation, we found a fair and significant correlation between 8-OHdG and FMA (r = −0.34) and 8-OHdG and pain (r = 0.26, p < 0.05). Baseline 8-OHdG was significantly correlated with post-treatment FMA, MRC, and pain scores (r = −0.34, −0.31, and 0.25; p < 0.05), indicating its ability to predict functional outcomes. 8-OHdG levels were significantly decreased, and functional outcomes were improved after rehabilitation. The exploratory study findings conclude that 8-OHdG is a reliable and promising biomarker of oxidative stress and could be a valid predictor of functional outcomes in patients. Monitoring of behavioral indicators along with biomarkers may have crucial benefits in translational stroke research.

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“…The OXY adsorbent test quantifies the ability of the plasma antioxidant compounds to buffer a massive oxidation through hypochlorous acid. This assay measures a variety of nonenzymatic antioxidants, including vitamins, carotenoids, flavonoids and thiols (OXY significantly correlate with thiols in the blood: r = 0.65-0.67, Palleschi et al 2007). Antioxidant capacity is expressed as mM of HClO neutralised.…”

Section: Sampling and Laboratory Analysismentioning

confidence: 99%

Environmental conditions can modulate the links among oxidative stress, age, and longevity

Marasco

Stier

Boner

et al. 2017

Mechanisms of Ageing and Development

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* Joint first authorsHighlights  We exposed zebra finch females to challenging environmental conditions  We examined treatment effects on age-related changes in oxidative stress (OS)  Levels of damage to DNA and proteins increased with chronological age  The treatment produced a higher age-related increase in the level of damage to DNA  We found treatment-specific links among OS and longevity Corresponding author: Pat.Monaghan@glasgow.ac.uk 2 AbstractUnderstanding the links between environmental conditions and longevity remains a major focus in biological research. We examined within-individual changes between early-and midadulthood in the circulating levels of four oxidative stress markers linked to ageing, using zebra finches (Taeniopygia guttata): a DNA damage product (8-hydroxy-2'-deoxyguanosine; 8-OHdG), protein carbonyls (PC), non-enzymatic antioxidant capacity (OXY), and superoxide dismutase activity (SOD). We further examined whether such within-individual changes differed among birds living under control (ad lib food) or more challenging environmental conditions (unpredictable food availability), having previously found that the latter increased corticosterone levels when food was absent but improved survival over a three year period. Our key findings were: (i) 8-OHdG and PC increased with age in both environments, with a higher increase in 8-OHdG in the challenging environment; (ii) SOD increased with age in the controls but not in the challenged birds, while the opposite was true for OXY; (iii) control birds with high levels of 8-OHdG died at a younger age, but this was not the case in challenged birds. Our data clearly show that while exposure to the potentially damaging effects of oxidative stress increases with age, environmental conditions can modulate the pace of this age-related change.

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Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study

Cited by 23 publications

References 39 publications

Estimation of Oxidative Stress Markers in Chronic Kidney Disease

Estimation of Oxidative Stress Markers in Chronic Kidney Disease

The Reliability and Predictive Ability of a Biomarker of Oxidative DNA Damage on Functional Outcomes after Stroke Rehabilitation

Environmental conditions can modulate the links among oxidative stress, age, and longevity

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