Literature shows that intolerance of uncertainty can negatively affect health professionals' medical decision-making process. However, there is no intolerance of uncertainty measurement tools in French, so this study aimed at validating the Intolerance of Uncertainty Scale-12 (IUS-12) in French, and a version of the IUS-12 adapted for healthcare professionals (IUS-12-H). We asked health professionals to complete our two scales of interest, as well as several scales covering related constructs. Five hundred and sixteen health professionals completed French versions of the IUS-12 and the IUS-12-H, and our additional scales. Exploratory factor analyses showed that the IUS-12 and IUS-12-H scales had a two-factor structure as in the seminal article of Carleton et al. (2007). The IUS-12 and the IUS-11-H French versions show psychometric properties comparable to the original version indicating that they can be used as the seminal scales for French health professionals.