Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO©) Scores in Influenza-Positive Patients

Powers, John H.; Bacci, Elizabeth D.; Guerrero, M. Lourdes; Leidy, Nancy Kline; Stringer, Sonja; Kim, Katherine; Memoli, Matthew J.; Han, Alison; Fairchok, Mary; Chen, Wei Ju; Arnold, John; Danaher, Patrick; Lalani, Tahaniyat; Ridoré, Michelande; Burgess, Timothy; Millar, Eugene V.; Hernández, Andrés; Rodríguez‐Zulueta, Patricia; Smolskis, Mary; Ortega-Gallegos, Hilda; Pett, Sarah; Fischer, William A.; Gillor, Daniel; Macias, Laura Moreno; DuVal, Anna; Rothman, Richard E.; Dugas, Andrea; Ruíz-Palacios, Guillermo M.

doi:10.1016/j.jval.2017.04.014

Cited by 35 publications

(53 citation statements)

References 17 publications

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“…Moreover, transmission with stool is also a neglected risk for SARS[21]. During the infection of SARS and highly pathogenic strains of influenza, their enteric symptoms are associated with the increased permeability to intestinal lipopolysaccharide (LPS) and bacterial transmigration through gastrointestinal wall[22, 23]. However, the mechanism of 2019-nCov-induced enteric symptom is still unknown.…”

Section: Discussionmentioning

confidence: 99%

The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

Zhang

Kang

Gong

et al. 2020

Preprint

564

538

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1 Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2 2019-nCov) is causing outbreak of pneumonia in one of largest cities, Wuhan, in 3 Hubei province of China and has draw significant public health attention. The same as 4 severe acute respiratory syndrome coronavirus (SARS-CoV), 2019-nCov enters into 5 host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to 6 dissect the ACE2-expressing cell composition and proportion and explore a potential 7 route of the 2019-nCov infection in digestive system infection, 4 datasets with 8 single-cell transcriptomes of lung, esophagus, gastric, ileum and colon were analyzed.9

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Section: Discussionmentioning

confidence: 99%

The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

Zhang

Kang

Gong

et al. 2020

Preprint

564

538

View full text Add to dashboard Cite

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“…Further studies should be done using direct measures of patient health status such as intensity and duration of participants' symptoms or complications (eg, pneumonia). We have developed a symptom scale for influenza (FLU-PRO) as part of the study ILI-002 that could be used in future studies [38].…”

Section: Discussionmentioning

confidence: 99%

Comparison of rates of hospitalization between single and dual virus detection in a Mexican cohort of children and adults with influenza-like illness

Noyola

Hunsberger

Salgado

et al. 2019

Open Forum Infectious Diseases

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Background. Molecular detection methods allow for the simultaneous detection of several infectious agents. This study assesses whether co-infection with 2 viruses as compared with 1 is associated with increased hospitalization in those with acute respiratory infections.Methods. We prospectively enrolled a cohort of pediatric and adult participants with influenza-like illness during 2010-2014 in Mexico. Clinical information and respiratory samples were collected at enrollment. Respiratory viruses were detected with multiplex polymerase chain reaction (PCR) and influenza-specific reverse transcription PCR assays. Participants were followed for 14 and 28 days after inclusion. Severity of disease, as measured by hospitalization with acute respiratory infections, was compared between single and dual viral infections.Results. Among 5662 participants in the study, either 1 (n = 3285) or 2 (n = 641) viruses were detected in 3926 participants. Rhinovirus (n = 1433), influenza (n = 888), and coronaviruses (n = 703) were the most frequently detected viruses (either alone or in co-infection). Bocavirus, respiratory syncytial virus (RSV), metapneumovirus, and rhinovirus cases were hospitalized more often than other viruses. Bocavirus+rhinovirus cases were hospitalized more often than those with rhinovirus alone (but not bocavirus alone). RSV cases were more likely to be hospitalized than cases with co-infections of RSV and parainfluenza virus or coronavirus. Metapneumovirus cases were hospitalized more often than those co-infected with metapneumovirus+coronavirus.Conclusions. In this study, detection of 2 viruses did not significantly increase hospitalizations compared with single virus infections. Larger studies will allow for distinguishing between sequential and simultaneous infection and for a better understanding of the role of each virus during the evolution of acute respiratory episodes.

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“…Clinical symptoms were assessed using the FLU-PRO Symptom Severity Assessment Tool, a participant-directed questionnaire designed to assess influenza disease severity that has been validated in both natural infection and influenza challenge studies [39][40][41] . In addition, a physician assessment was also performed daily for 10 days to determine the presence or absence of influenza signs/symptoms.…”

Section: Clinical Evaluationmentioning

confidence: 99%

Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study

et al. 2020

Self Cite

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FLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, phase IIb efficacy and safety trial was conducted. One hundred and fifty-three healthy individuals 18-55 years of age were randomized to receive one or two doses of adjuvanted FLU-v or adjuvanted placebo subcutaneously on days −43 and −22, prior to intranasal challenge on day 0 with the A/California/04/ 2009/H1N1 human influenza A challenge virus. The primary objective of the study was to identify a reduction in mild to moderate influenza disease (MMID) defined as the presence of viral shedding and clinical influenza symptoms. Single-dose adjuvanted FLU-v recipients (n = 40) were significantly less likely to develop MMID after challenge vs placebo (n = 42) (32.5% vs 54.8% p = 0.035). FLU-v should continue to be evaluated and cellular immunity explored further as a possible important correlate of protection against influenza.npj Vaccines (2020) 5:22 ; https://doi.

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Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO©) Scores in Influenza-Positive Patients

Abstract: Results suggest that FLU-PRO scores are reliable, valid, and responsive to change in influenza-positive adults.

Cited by 35 publications

References 17 publications

The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

Comparison of rates of hospitalization between single and dual virus detection in a Mexican cohort of children and adults with influenza-like illness

Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study

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