We present a novel ultra-wideband low-cost transmit/receive architecture with reduced power and hardware requirements, which includes interference mitigation capabilities and accommodates multiple users. Specifically, a novel encoding approach is introduced to multiplex signals across large bandwidths and achieve secure communication and interference mitigation through spread signals. In this paper, a detailed description of the proposed high data rate system architecture is presented. Simulations are also provided in the presence of high-power interferers with eight concurrent users. To assess the performance and impact of the encoding/decoding process, a noise analysis was conducted for the transmitter and receiver chains. Specifically, bit error rate curves are generated at different stages of the system. The measurements show interference margin ratios improvement by at least 16 dB.