Citation: Castellano-tejedor C. the challenges of psycho-oncology research in developing countries: a non-equivalent process of growth. adv mod oncol res 2017; 3(S1): [45][46] Psycho-oncology emerged only four decades ago. this discipline, as a subspecialty into the disease-specific domain of oncology, is focused on the psychological aspects of the treatment and management of patients with cancer. Today, this field contributes to the clinical care of patients and their families, to the training of staff in psychological management, and to collaborative research that ranges from the behavioral issues in cancer prevention to the management of psychiatric disorders and the psychosocial problems during the continuum of cancer illness, including survivorship and end-of-life care [1] . Despite the relatively short lifespan of psycho-oncology specialty, the extent of its clinical influence and the amount of research produced is enormous. the development of psycho-oncology has been closely related to the development of the medical practice of oncology. During the last decade, we have witnessed an unprecedented outburst of new treatment approaches for cancer and new lines of research have arisen. these progresses and cancer control research have helped to reduce cancer incidence, morbidity and mortality [2] . as a consequence, survivorship as the ultimate goal of oncology is not an exception anymore. now, this is a common expected outcome and cancer survivors are a growing population [3] . Besides, cancer is now considered as a chronic condition more than a death sentence. therefore, the focused is placed not strictly on survival, but in improving adaptation to the disease and the global health status in the aftermath of cancer [4] . Precisely, psycho-oncology research is aimed at examining long-term psychosocial effects of treatment, survival, health-related quality of life, adaptation to cancer and to a life free of treatment and the disease, among other aspects [1] . all these aforementioned issues constitute the basis of a growing body of knowledge and the foundations of this field. However, there are still several challenges to overcome. It is already known that, in psycho-oncology research, comparisons and generalizations are very difficult because of the variety of settings, sample populations, study designs, assessment tools, and operational definitions of constructs and variables studied. to these limitations, we must include resource availability differences depending on the country. In this sense, it is worthwhile to stress that approximately 70% of all cancer deaths occur in low-and middleincome countries [5] . that is to say, the ethnic minorities are overrepresented in cancer burden, yet underrepresented in research. Psycho-oncology (and oncology research, in general) has followed the guiding path of resources availability. that means that most scientific research in this area does not include unique aspects from developing countries. this represents a big limitation because practical models for designing m...