Religionssoziologie

Kehrer, Günter

doi:10.1515/9783110829174

Cited by 5 publications

(1 citation statement)

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“…13 However, substrates for these processes employ aryl or vinyl boronates as oxidative triggers to promote release from the benzylic or allylic position. Therapeutic applications of these systems, therefore, can be complicated by the significant toxicity of the resultant quinone methide 14 or acrolein 15 byproducts. Thus, alternative structural motifs that release compounds in the presence of H 2 O 2 without generating toxic byproducts would be valuable for applications in oxidative drug release.…”

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confidence: 99%

Alcohol, Aldehyde, and Ketone Liberation and Intracellular Cargo Release through Peroxide-Mediated α-Boryl Ether Fragmentation

et al. 2016

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α-Boryl ethers, carbonates, and acetals, readily prepared from the corresponding alcohols that are accessed through ketone diboration, react rapidly with hydrogen peroxide to release alcohols, aldehydes, and ketones through the collapse of hemiacetal intermediates. Experiments with α-boryl acetals containing a latent fluorophore clearly demonstrate that cargo can be released inside cells in the presence of exogenous or endogenous hydrogen peroxide. These experiments show that this protocol can be used for drug activation in an oxidative environment without generating toxic byproducts.

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confidence: 99%