Despite widespread, wide-ranging and often straightforward, easily graspable criticisms of its core premises, the idea that religion and science are opposed to one another has proved remarkably resilient. Given how easy the notion is to rebut, it is not therefore the theoretical question (How are religion and science opposed to one another, if at all?) but the empirical one (What is the basis of this problematic binary and its hold over popular and scholarly imaginations?) that is arguably the most compelling.The goal of this chapter is to consider this question from the perspective of non-religion and secularity studies (Bullivant and Lee 2012), focusing in particular on the relationship between science and non-religiosity. It builds on ideas arising from critical secular studies and critical religion studies, both of which challenge the idea that science mainly impacts on religion epistemically, and instead draw attention to the ideological and mythological roles that science plays in the subjectivities, identities and cultures of non-religious people.The chapter uses the UK as a case study for understanding the role of science within non-religious cultural formations found more widely, especially across Europe and other Western regions.The aim of this chapter is to contribute to – and further encourage – the more localised and detailed empirical explorations of perceived non-religion/science affinity that are just beginning to emerge.