Background: Though adolescence is recognised as a critical period for smoking prevention, there is a lack of research focused on this issue in Kosovo. The aim of this study has been to examine the gender-specific factors of influence (predictors) for smoking among adolescents in Pristina, Kosovo. Material and Methods: The study sample comprised 1002 adolescents at the age of 17-18 (366 boys, 636 girls), all of whom were in the school's 12th grade. The predictors included sociodemographic variables, familial (i.e., parental) monitoring, parents' educational background, and sport-related factors. The Chi 2 and forward stepwise logistic regression analyses with a dichotomous criterion (smoking vs. non-smoking) were applied. Results: The incidence of smoking was high (31% and 40% smokers, including 7% and 12% daily smokers for girls and boys, respectively). The regression model revealed more frequent absence from school (odds ratio (OR): 1.544; 95% confidence interval (CI): 1.063-2.243), more unexcused school absences (OR: 1.360; 95% CI: 1.029-1.796), and frequent parental questioning (OR: 1.530; 95% CI: 1.020-2.295) to be significant predictors of smoking among boys. For girls, a higher risk of smoking was associated with lower scholastic achievement (OR: 1.467; 95% CI: 1.089-1.977), more frequent absence from school (OR: 1.565; 95% CI: 1.137-2.155), increased conflict with parents (OR: 1.979; 95% CI: 1.405-2.789), and a self-declared perception of less parental care (OR: 0.602; 95% CI: 0.377-0.962). Sports were not found to be strongly related to smoking. However, a high risk of daily smoking was found among boys who participated in team sports and subsequently quit. Conclusions: This study reinforces the need for gender-and culture-specific approaches to studying the factors that influence smoking among adolescents. Med Pr 2015;66(2):153-163