In this paper, we investigate the use of first-order reliability methods to quantify the uncertainty in the remaining useful life (RUL) estimate of components used in engineering applications. The prediction of RUL is affected by several sources of uncertainty, and it is important to systematically quantify their combined effect on the RUL prediction in order to aid risk assessment, risk mitigation, and decision-making. While sampling-based algorithms have been conventionally used for quantifying the uncertainty in RUL, analytical approaches are computationally cheaper, and sometimes they are better suited for online decision-making. Exact analytical algorithms may not be available for practical engineering applications, but effective approximations can be made using first-order reliability methods. This paper describes three first-order reliability-based methods for RUL uncertainty quantification: first-order second moment method (FOSM), the firstorder reliability method (FORM), and the inverse first-order reliability method (inverse-FORM). The inverse-FORM methodology is particularly useful in the context of online health monitoring, and this method is illustrated using the power system of an unmanned aerial vehicle, where the goal is to predict the end of discharge of a lithium-ion battery.Index Terms-Analytical algorithms, first-order reliability method, ithium-ion battery, model-based prognostics, probability distribution, remaining useful life, uncertainty.