Remarkable differences in double-flash-response in rod-dominated and mixed retina

Schulze, Jost; Beddermann, F.

doi:10.1016/0042-6989(71)90180-5

Cited by 2 publications

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“…With this method the influence of preceding stimuli or preceding responses on the excitability of retinal receptors and neuroretinal cells can be studied. Results of measurements in cats [1][2][3], rabbits [4][5][6], frogs [5] and normal human eyes [7][8][9], with and without the use of agonistic or antagonistic drugs, have been published in the last 40 years. In a recent study on patients with Parkinson's disease, decreased suppression of the responses to the test flashes compared to suppression in matched normal subjects was found [10].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

et al. 1991

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Neural adaptation to light stimulation in the dark-adapted retina can be demonstrated by double-flash electroretinography. The first flash is a conditioning flash, the second flash is the test flash. Interstimulus intervals are in the range of 0.2 to 30 seconds. Suppression of the response to the test flash is assumed not to be related to photopigment regeneration, as in normal human subjects the recovery after strong conditioning flashes is completed in about 2 seconds. In this paper we demonstrate the results of double-flash electroretinography on four patients, two of whom are brother and sister. Each of them showed a five- to ten-fold prolonged suppression time compared to normal measurements. Clinical aspects of all the patients were a stationary, though fluctuating, subnormal visual acuity of about 0.5, some photophobia, and difficulties in adaptation to changes in luminance levels. We assume that the PERRS indicates changes in the restorative reactions to phototransduction in the photoreceptors, or in the neural transmission mechanism, either in the rod-driven lateral inhibitory neural processes or in the cone-driven rod inhibitory processes, caused by a cone dysfunction.

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Section: Introductionmentioning

confidence: 99%

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

et al. 1991

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“…For several decades, double-flash electroretinography (ERG) has been used to study the interaction and processing of the retinal responses in intact eyes [1][2][3][4][5][6][7][8][9]. Increasing knowledge about the roles of different cells in retinal neurotransmission [10][11][12][13] has renewed the interest in this method [14, 15; Zwartz M J, et al Double-flash electroretinography in Parkinson's disease, submitted for publication].…”

Section: Introductionmentioning

confidence: 99%

Double-flash electroretinography in human eyes

Kooijman¹,

Zwarts

Damhof³

1989

Doc Ophthalmol

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A tri-color Ganzfeld stimulator with light-emitting diodes as light sources is used to study the suppression of the second electroretinographic response in human eyes to double-flash stimulation. The mechanism suppressing the a- and b-waves of the response to the second (test) flash has a scotopic spectral sensitivity to the first (conditioning) flash. Responses to mild test stimuli are more sensitive to suppression by a conditioning flash than responses to strong test stimuli.

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Remarkable differences in double-flash-response in rod-dominated and mixed retina

Cited by 2 publications

References 0 publications

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

Double-flash electroretinography in human eyes

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