Remarkable Weight Reduction for Low Carbohydrate Diet (LCD): Case Report

Bando, Hiroshi; Ebe, Koji; Sakamoto, Kazuki; Ogawa, Tomoya; Bando, Masahiro; Yasuda, Yoshikazu

doi:10.4172/2572-5629.1000130

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…[2][3][4]9 More recently, genetically encoded fluorescent indicators have emerged as another useful approach for monitoring membrane potentials. [10][11][12][13] We have initiated a program to develop voltage-sensitive fluorophores with high response kinetics and high voltage sensitivity to enable single trial detection of action potentials and voltage dynamics in living cells. Our hypothesis is that this new class of voltage-sensitive fluorophores, or VoltageFluors, would utilize photoinduced electron transfer (PeT) as the trigger to transduce changes in membrane potential into changes in fluorescence intensity (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators

Liu

Miller

2019

Acc. Chem. Res.

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Membrane potential is a fundamental biophysical property maintained by every cell on earth. In specialized cells like neurons, rapid changes in membrane potential drives the release of chemical neurotransmitters. Coordinated, rapid changes in neuronal membrane potential across large numbers of interconnected neurons forms the basis for all of human cognition, sensory perception, and memory. Despite the importance of this highly orchestrated and distributed activity, the traditional method for recording membrane potential is through the use of highly invasive, singlecell electrodes that offer only a small glimpse of the total activity within a system. Fluorescent dyes that change their optical properties in response to changes in biological voltage have the potential to provide a powerful complement to traditional, electrode-based methods of inquiry. Voltage-sensitive fluorescent indicators would allow the direct observation of membrane potential changes, significantly expanding our ability to monitor membrane potential dynamics in living systems.

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Section: Introductionmentioning

confidence: 99%

Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators

Liu

Miller

2019

Acc. Chem. Res.

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“…Furthermore, we clarified the physiological important role of ketone bodies in the axis of fetus, placenta, newborn and mother, and associated changes of renal and lipid aspects [9][10][11][12]. Through our clinical research about LCD and ketone bodies, we have accumulated lots of experiences of treatment for type 2 diabetes mellitus (T2DM) by super LCD therapeutic meal [13,14].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Elevated Ketone Bodies in Low Carbohydrate Diet (LCD)

Bando¹,

Ebe²,

Muneta³

et al. 2017

Intern Med

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“…The authors' diabetic research group has been reporting for a long time, covering areas such as Carbo-70g breakfast loading, meal tolerance test (MTT), low carbohydrate diet (LCD), and various cases with continuous glucose monitoring (CGM) and OHAs [14,15]. Among their recent reports, pharmacological efficacy of imeglimin (Twymeeg) has been introduced [16].…”

Section: Introductionmentioning

confidence: 99%

Combined Treatment of Vildagliptin/Metformin (Equmet) and Imeglimin (Twymeeg) with Clinical Efficacy

Bando

Yamashita

Kato

et al. 2023

Asp Biomed Clin Case Rep

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Background: Vildagliptin/Metformin (EquMet) and imeglimin (Twymeeg) are effective oral hypoglycemic agents (OHAs) for patients with type 2 diabetes (T2D). Case Presentation: The patient was a 68-year-old male with T2D and fatty liver for several years. In November 2022, his HbA1c had increased to 8.2%, and he was started on Twymeeg, followed by EquMet. Results: Over the course of four months, the patient’s HbA1c value successfully decreased from 8.2% to 6.7%, and he did not experience any gastrointestinal adverse effects (GIAEs). Discussion and Conclusion: The combined treatment of EquMet and Twymeeg demonstrated clinical efficacy without any adverse effects. The Trials of IMeglimin for Efficacy and Safety (TIMES) provided various evidence of imeglimin’s effectiveness.

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Remarkable Weight Reduction for Low Carbohydrate Diet (LCD): Case Report

Abstract: Background: There have been discussion for years concerning Calorie Restriction (CR) and low carbohydrate diet (LCD). As to LCD, we have reported clinical experience and research for glucose variability and ketone bodies.

Cited by 4 publications

References 12 publications

Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators

Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators

Investigation of Elevated Ketone Bodies in Low Carbohydrate Diet (LCD)

Combined Treatment of Vildagliptin/Metformin (Equmet) and Imeglimin (Twymeeg) with Clinical Efficacy

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