Remdesivir treatment in hospitalized patients affected by COVID‐19 pneumonia: A case‐control study

Abstract

To date the optimal antiviral treatment against severe coronavirus disease 2019 (COVID‐19) has not been proven; remdesivir is a promising drug with in vitro activity against several viruses, but in COVID‐19 the clinical results are currently not definitive. In this retrospective observational study, we analyzed the clinical outcomes (survival analysis, efficacy, and safety) in a group of hospitalized patients with COVID‐19 treated with remdesivir in comparison with a control group of patients treated with other antiviral or supportive therapies. We included 163 patients treated with remdesivir and 403 subjects in the control group; the baseline characteristics were similar in the two groups; the mortality rate was higher in the control group (24.8% vs. 2.4%, p < 0.001), the risk of intensive care unit (ICU) admission was higher in the control group (17.8% vs. 9.8%, p = 0.008); hospitalization time was significantly lower in patients treated with remdesivir (9.5 vs. 12.5 days, p < 0.001). The safety of remdesivir was good and no significant adverse events were reported. In multivariate analysis, the remdesivir treatment was independently associated with a 34% lower mortality rate (odds ratio = 0.669; p = 0.014). In this analysis, the treatment with remdesivir was associated with lower mortality, lower rate of ICU admission, and shorter time of hospitalization. No adverse events were observed. This promising antiviral treatment should also be confirmed by other studies.

Genetic Study of SARS-CoV-2 Non Structural Protein 12 in COVID-19 Patients Non Responders to Remdesivir

“…The nucleoside analog is incorporated into the generating RNA strand and evades proofreading to successfully inhibit viral RNA synthesis. Several clinical trials and a recent case-control study demonstrated reduced time to recovery, hospitalization time, morbidity, and mortality ( 8 – 10 ).…”

Clinico-morphological particularities of COVID-19 pneumonia

“…However, some antiviral drugs used in various studies have shown significant effects, such as reducing viral load, improving overall condition, and reducing hospitalization time. Generally, antiviral treatment should be initiated as early as possible to reduce viral replication and improve patient prognosis [20,22,21].…”

Anti-inflammatory effects of medications used for viral infection-induced respiratory diseases

“…Boglione et al. found that treatment with remdesivir was associated with a lower rate of mortality and intensive care unit (ICU) admission and a shorter time of hospitalization in a case-control study [ 120 ]. Marrone et al.…”