Remediable Defects in Crohn Disease

Beeken, Warren L.

doi:10.1001/archinte.1975.00330050060010

Cited by 46 publications

(3 citation statements)

References 27 publications

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“…Their etiology is unknown so far: beside immunological and genetic factors, microbial and dietary ones may also be involved [9, 10, 17, 201. It is well-known, that in CROHN'S disease, due primarily to absorption disturbances, hypoproteinemia and anemia occur [2,6]. Fat malabsorption [2,6, 1 13 and disturbances in the absorption of the bile acids [8, 121 are reported features. The decrease of serum retinol level was reported, which may be explained partly by fat malabsorption and partly by the decreased retinol-binding protein level [ 1522,261.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammatory bowel disease comprises two syndromes : CROHN'S disease, which is the granulomatous inflammation of all layers of the distal quarter of the small intestine and ulcerative colitis which is the ulcerative inflammation of the colon, involving only the mucosa. Their etiology is unknown so far: beside immunological and genetic factors, microbial and dietary ones may also be involved [9, 10, 17, 201. It is well-known, that in CROHN'S disease, due primarily to absorption disturbances, hypoproteinemia and anemia occur [2,6]. Fat malabsorption [2,6, 1 13 and disturbances in the absorption of the bile acids [ Fat-and retinol loadings were performed in patients and in 20 healthy volunteers: boiled and mashed potatoes, mixed with butter (2 g/kg body mass) and retinol acetate (300 IU/kg body mass) were served.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors found connection between the decrease of lactase activity and ulcerative colitis[4], as opposed to other [19], sucrase and maltase activities did not differ from those observed in the healthy population [l]. Mild hypomagnesemia was reported[2, 13, 241. No data were found on the fat-and retinol absorption in patients with ulcerative colitis.…”

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Effect of fat and retinol loading on serum triglyceride and retinol levels in patients with ulcerative colitis

Regöly-Mérei

Ferencz

Frenkl

et al. 1991

Nahrung

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Serum copper, zinc, selenium, magnesium, calcium, cholesterol, triglyceride and retinol contents were determined in 11 patients with ulcerative colitis and in 20 healthy volunteers. Lipid and retinol loadings were performed as well. No differences were found in serum copper, zinc, calcium and selenium levels between the groups. Serum magnesium levels were somewhat lower in the patients than in the volunteers. During the period of loading, cholesterol levels did not differ between the two groups at any time. Triglyceride levels except for two persons, were higher in patients. Triglyceride curves showed pathological courses in each case. Retinol concentrations in patients remained below the values observed in volunteers. Data suggest a disturbed utilization of fat and retinol in patients with ulcerative colitis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of fat and retinol loading on serum triglyceride and retinol levels in patients with ulcerative colitis

Regöly-Mérei

Ferencz

Frenkl

et al. 1991

Nahrung

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Extraintestinal Consequences of Mucosal Inflammation

Bourikas

Papadakis

2010

Inflammatory Bowel Disease

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Intestinal ferroportin expression in pediatric Crohnʼs disease

Burpee

Mitchell

Fishman

et al. 2011

Inflammatory Bowel Diseases

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Background Anemia is a frequent complication of Crohn’s disease (CD). The intestinal iron exporter ferroportin (FPN) is involved in both iron deficiency anemia and the anemia of chronic disease. To examine its role in CD, intestinal FPN expression was studied in subjects with and without CD. Methods Duodenal mucosal biopsies from 29 pediatric subjects with CD (n = 19) and without CD (n = 10) were obtained. FPN protein was measured using Western blot analysis and mRNA was assessed using quantitative real-time polymerase chain reaction (PCR). Results Intestinal FPN protein was higher in anemic CD subjects than in nonanemic CD subjects (P = 0.01), while FPN mRNA levels were not different (P = 0.66). In nonanemic CD subjects, erythrocyte sedimentation rate (ESR) (P = 0.04), C-reactive protein (CRP) (P = 0.03), and interleukin-6 (IL-6) (P = 0.01) levels were elevated compared to controls. Nonanemic CD subjects had a lower median FPN protein than nonanemic controls, although it did not reach statistical significance (P = 0.07). Median FPN mRNA was similar between groups (P = 0.71). Although no correlation between FPN protein and IL-6 was noted, there was a strong negative correlation between serum iron and IL-6, both in subjects with CD (r = −0.88, P < 0.0001) and those without anemia (r = −0.58, P = 0.02). Conclusions Intestinal FPN protein is upregulated in anemic CD subjects, suggesting that iron deficiency or anemia is the driving force regulating FPN levels. A transporter distinct from FPN appears to be involved in the hypoferremia associated with the inflammatory process of CD.

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Remediable Defects in Crohn Disease

Cited by 46 publications

References 27 publications

Effect of fat and retinol loading on serum triglyceride and retinol levels in patients with ulcerative colitis

Effect of fat and retinol loading on serum triglyceride and retinol levels in patients with ulcerative colitis

Extraintestinal Consequences of Mucosal Inflammation

Intestinal ferroportin expression in pediatric Crohnʼs disease

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