Remineralization Potential of a New Toothpaste Formulation: An In-Vitro Study

Torrado, Anna; Valiente, Manuel; Zhang, Wu; Li, Yiming; Muñoz, Carlos

doi:10.5005/jcdp-5-1-18

Cited by 14 publications

(1 citation statement)

References 18 publications

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“…Remineralisation, in turn, develops as restoration of partially dissolved crystals, new crystal formation, or growth of surviving crystals [6]. Demineralization and remineralization can be considered as a dynamic processes, characterized by the flow of calcium and phosphate out of and back into tooth enamel [7]. Both remineralisation and demineralisation influence structural and morphological parameters of enamel, altering its features and changing its arrangement.…”

Section: Introductionmentioning

confidence: 99%

Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP–ACP Compound

et al. 2020

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Changes to the features of the enamel surface submitted to induced demineralisation and subsequent remineralisation were studied. The in vitro examination was conducted on polished slices of human molar teeth, divided in four groups: the untreated control (n = 20), challenged by a demineralisation with orthophosphoric acid (H3PO4) (n = 20), and challenged by a demineralisation following remineralisation with fluoride (F) varnish containing casein phosphopeptides (CPP) and amorphous calcium phosphate (ACP) compounds (n = 20). The specimens’ enamel surfaces were subjected to analysis of structure, molecular arrangement, mechanical features, chemical composition, and crystalline organization of apatite crystals. Specimens treated with acid showed a significant decrease in crystallinity, calcium, and phosphorus levels as well as mechanical parameters, with an increase in enamel surface roughness and degree of carbonates when compared to the control group. Treatment with fluoride CPP–ACP varnish provided great improvements in enamel arrangement, as the destroyed hydroxyapatite structure was largely rebuilt and the resulting enamel surface was characterised by greater regularity, higher molecular and structural organisation, and a smoother surface compared to the demineralised one. In conclusion, this in vitro study showed that fluoride CPP–ACP varnish, by improving enamel hardness and initiating the deposition of a new crystal layer, can be an effective remineralising agent for the treatment of damaged enamel.

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Section: Introductionmentioning

confidence: 99%

Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP–ACP Compound

et al. 2020

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The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

2022

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This study aims to develop an innovative dental product to remineralize dental enamel by a proper combination of ion-exchange resins as controlled release of mineral ions that form dental enamel, in the presence of amelogenin to guide the appropriate crystal growth. The novel product proposed consists of a combination of ion-exchange resins (weak acid and weak base) individually loaded with the remineralizing ions: Ca2+, PO43− and F−, also including Zn2+ in a minor amount as antibacterial, together with the protein amelogenin. Such cocktail provides onsite controlled release of the ions necessary for enamel remineralization due to the weak character of the resins and at the same time, a guiding tool for related crystal growth by the indicated protein. Amelogenin protein is involved in the structural development of natural enamel and takes a key role in controlling the crystal growth morphology and alignment at the enamel surface. Bovine teeth were treated by applying the resins and protein together with artificial saliva. Treated teeth were evaluated with nanoindentation, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The innovative material induces the dental remineralization creating a fluorapatite layer with a hardness equivalent to sound enamel, with the appropriate alignment of corresponding nanocrystals, being the fluorapatite more acid resistant than the original mineral. Our results suggest that the new product shows potential for promoting long-term remineralization leading to the inhibition of caries and protection of dental structures.

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Principles of demineralization: Modern strategies for the isolation of organic frameworks

Ehrlich

Koutsoukos

Demadis

et al. 2008

Micron

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Remineralization Potential of a New Toothpaste Formulation: An In-Vitro Study

Cited by 14 publications

References 18 publications

Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP–ACP Compound

Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP–ACP Compound

The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

Principles of demineralization: Modern strategies for the isolation of organic frameworks

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