Remisión de la epilepsia tras el comienzo del tratamiento: estudio prospectivo en la infancia

Early prediction of refractory epilepsy in childhood

“…7 In a previous study carried out by our group, which involved a different sample, recurrence of seizures in the first 6 months of treatment diminished the probability of achieving a 2-year initial remission and a 3-year terminal remission without treatment. 17,24 In our new study, the risk of developing refractory epilepsy was 19% (95% CI: 12-26) at 6 years in children with more than one recurrence in the first 6 months after diagnosis compared to 2% (95% CI: 0-4) in those with only one or no recurrences. This association was significant in univariable and multivariable analyses.…”

“…Prospective studies in children and adults with recent-onset epilepsy have found a probability of achieving a 2-year initial remission of 80-90% at 5-9 years. [13][14][15][16][17][18] However, some patients cannot be controlled adequately with antiepileptic medication and develop refractory (intractable) epilepsy. The definition of refractory epilepsy varies in different studies.…”

Response to sequential treatment schedules in childhood epilepsy

“…The probability of achieving a 2-year initial remission was 81% and 90% at 5 and 10 years, respectively. Some studies, 13,14 including a large population-based one 15 and two studies dealing exclusively with children 16,17 have found similar results (probability of achieving a 2-year remission in the range of 81-90% at 5-9 years). Moreover, seizures were ''controlled'' in 70% of patients at 5 years and in 86% at 10 years.…”