Remodeled salt appetite in rat offspring by perinatal exposure to nicotine

Hui, Pengpeng; Cheng, Rui; Liu, Yujuan; Xu, Fulin; Wu, Jiawei; Wu, Lei; Chen, Yu; Liao, Jiawei; Mao, Caiping; Xu, Zhice

doi:10.1016/j.appet.2008.12.013

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…In a rat model of prenatal nicotine exposure, female but not male offspring were found to have reduced water intake after a water deprivation challenge compared to controls (Hui et al. ). This was associated with reduced levels of Agtr1 and Agtr2 protein in the forebrain of nicotine‐exposed female offspring.…”

Section: Discussionmentioning

confidence: 99%

Maternal corticosterone exposure in the mouse programs sex-specific renal adaptations in the renin-angiotensin-aldosterone system in 6-month offspring

et al. 2016

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Short‐term maternal corticosterone (Cort) administration at mid‐gestation in the mouse reduces nephron number in both sexes while programming renal and cardiovascular dysfunction in 12‐month male but not female offspring. The renal renin–angiotensin–aldosterone system (RAAS), functions in a sexually dimorphic manner to regulate both renal and cardiovascular physiology. This study aimed to identify if there are sex‐specific differences in basal levels of the intrarenal RAAS and to determine the impact of maternal Cort exposure on the RAAS in male and female offspring at 6 months of age. While intrarenal renin concentrations were higher in untreated females compared to untreated males, renal angiotensin II concentrations were higher in males than females. Furthermore, basal plasma aldosterone concentrations were greater in females than males. Cort exposed male but not female offspring had reduced water intake and urine excretion. Cort exposure increased renal renin concentrations and elevated mRNA expression of Ren1, Ace2, and Mas1 in male but not female offspring. In addition, male Cort exposed offspring had increased expression of the aldosterone receptor, Nr3c2 and renal sodium transporters. In contrast, Cort exposure increased Agtr1a mRNA levels in female offspring only. This study demonstrates that maternal Cort exposure alters key regulators of renal function in a sex‐specific manner at 6 months of life. These finding likely contribute to the disease outcomes in male but not female offspring in later life and highlights the importance of renal factors other than nephron number in the programming of renal and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Maternal corticosterone exposure in the mouse programs sex-specific renal adaptations in the renin-angiotensin-aldosterone system in 6-month offspring

et al. 2016

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“…Extracellular dehydration, induced by subcutaneous poly(ethylene glycol) injection, in pregnant rats results in an enhanced salt appetite in the adult offspring [19]. Other stimuli, such as exposure to a high-salt diet [20] or nicotine [21] in utero also increase the salt appetite of the offspring. Salt appetite is regulated by several hormones, including AngII (angiotensin II) produced both in the brain and the periphery [22].…”

Section: Figure 3 Ecf Volume (A) Total Body Water (B) and Total Bodymentioning

confidence: 99%

Prenatal programming of renal salt wasting resets postnatal salt appetite, which drives food intake in the rat

2011

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Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero) model of developmental programming because of increased renal NKCC2 (Na+/K+/2Cl- co-transporter 2) expression. However, we have shown that LP rats excrete more rather than less sodium than controls, leading us to hypothesize that LP rats ingest more salt in order to maintain sodium balance. Rats were fed on either a 9% (low) or 18% (control) protein diet during pregnancy; male and female offspring were studied at 4 weeks of age. LP rats of both sexes held in metabolism cages excreted more sodium and urine than controls. When given water to drink, LP rats drank more and ate more food than controls, hence sodium intake matched excretion. However, when given a choice between saline and water to drink, the total volume of fluid ingested by LP rats fell to control levels, but the volume of saline taken was significantly larger [3.8±0.1 compared with 8.8±1.3 ml/24 h per 100 g of body weight in control and LP rats respectively; P<0.001]. Interestingly food intake also fell to control levels. Total body sodium content and ECF (extracellular fluid) volumes were greater in LP rats. These results show that prenatal programming of renal sodium wasting leads to a compensatory increase in salt appetite in LP rats. We speculate that the need to maintain salt homoeostasis following malnutrition in utero stimulates greater food intake, leading to accelerated growth and raised BP (blood pressure).

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“…Several studies involving human subjects point to the heritability of various smoking-related phenotypes including initiation, dependence, failed smoking cessation and nicotine withdrawal (Berger et al, 2010;Biondolillo et al, 2009;Hui et al, 2009;Lessov et al, 2004;Rezvani et al, 2010). Nonetheless, the genetic mechanisms of the inheritance of nicotine addiction related behaviors have not been fully elucidated due to the genetic and phenotypic heterogeneity in the human population.…”

Section: Introductionmentioning

confidence: 99%

Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines

Nesil

Kanıt

Ugur

et al. 2015

Pharmacology Biochemistry and Behavior

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Remodeled salt appetite in rat offspring by perinatal exposure to nicotine

Cited by 9 publications

References 35 publications

Maternal corticosterone exposure in the mouse programs sex-specific renal adaptations in the renin-angiotensin-aldosterone system in 6-month offspring

Maternal corticosterone exposure in the mouse programs sex-specific renal adaptations in the renin-angiotensin-aldosterone system in 6-month offspring

Prenatal programming of renal salt wasting resets postnatal salt appetite, which drives food intake in the rat

Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines

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