Remodeling gut microbiota by Clostridium butyricum (C.butyricum) attenuates intestinal injury in burned mice

Zhang, Dongliang; Zhu, Cailin; Fang, Zhuoqun; Zhang, Hairui; Yang, Jingguo; Tao, Ke; Hu, Dahai; Han, Juntao; Yang, Xuekang

doi:10.1016/j.burns.2020.01.007

Cited by 14 publications

(13 citation statements)

References 34 publications

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“…According to Zhang et al. (2020), the Clostridium butyricum is beneficial for the homeostasis of intestinal microflora and suppression of inflammatory response. Therefore, even if FM‐PBM dietary treatment resulted in high hsp70 expression, which could be a sign of stress, this response could be beneficial for protection, as shown with the presence of this bacterium that could have been attenuated any other stress.…”

Section: Discussionmentioning

confidence: 99%

Prebiotic agavin in juvenile totoaba, Totoaba macdonaldi diets, to relieve soybean meal‐induced enteritis: Growth performance, gut histology and microbiota

Fuentes‐Quesada

Cornejo‐Granados²,

Mata-Sotres³

et al. 2020

Aquacult. Nutr.

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Section: Discussionmentioning

confidence: 99%

Prebiotic agavin in juvenile totoaba, Totoaba macdonaldi diets, to relieve soybean meal‐induced enteritis: Growth performance, gut histology and microbiota

Fuentes‐Quesada

Cornejo‐Granados²,

Mata-Sotres³

et al. 2020

Aquacult. Nutr.

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“…Actually, intestinal barrier plays an important role in the prevention of SAP risk [11], and SAP incidence can induce intestinal barrier injury [12]. The change of gut microbiota may lead to barrier failure, which is a key event contributing to the severity of gut injury [13,14]. Toll-like receptor 4-(TLR4-) dependent phosphatidylinositol 3-kinase (PI3K)/Protein kinase B (AKT)/NF-κB signaling is closely associated with oxidative stress and inflammatory responses [15,16].…”

Section: Introductionmentioning

confidence: 99%

Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota

Piao¹,

Liu

Sui

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Picroside II exerts anti-inflammatory and antidiarrheal effects for treating the diseases associated with oxidative injury. However, its function on pancreatitis-induced intestinal barrier injury remains unclear. Hypothesis/Purpose. We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-κB)). Study Design and Methods. A Sprague-Dawley (SD) rat model with severe acute pancreatitis (SAP) was induced via the injection of sodium taurocholate (4% wt/vol; 1 mL/kg). All rats were divided into 3 groups: sham (CG), SAP-induced intestinal barrier injury (MG), and picroside II (PG) groups. Intestinal barrier injury was assessed by scanning electron microscopy (SEM), hematoxylin and eosin staining, and pathological scores. We measured the levels of pancreatitis biomarkers (amylase and lipase), oxidative and inflammatory signaling (TLR4-dependent PI3K/AKT/NF-κB), oxidative stress marker (superoxidase dismutase (SOD), catalase (CAT), glutathione peroxidases (GPx), and malondialdehyde), and inflammatory markers (tumor necrosis factor α (TNFα), interleukin- (IL-) 1, IL-6, and IL-10) in serum and/or gut tissues. Gut microbiota composition in feces was measured by using 16S rRNA sequencing. Results. SEM showed that intestinal barrier injury was caused with the loss of intestinal villi and mitochondria destruction, and pathological scores were increased in the MG group. The levels of amylase, lipase, malondialdehyde, TNFα, IL-1, IL-6, TLR4, PI3K, AKT, and NF-κB were increased, and the levels of SOD, GPx, CAT, and IL-10 was reduced in the MG group when compared with CG group (P<0.05). Picroside II treatment inhibited the symptoms in the MG group and showed antioxidant and anti-inflammatory activities. The serum levels of picroside II had strong correlation with the levels of inflammatory and oxidative stress biomarkers (P<0.05). Picroside II treatment increased the proportion of Lactobacillus and Prevotella and decreased the proportion of Helicobacter and Escherichia_Shigella in the model. Conclusions. Picroside II improved the SAP-induced intestinal barrier injury in the rat model by inactivating oxidant and inflammatory signaling and improving gut microbiota.

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“…Zhang et al ., have investigated in a mouse model the role of Clostridium butyricum ( C. butyricum ) and its production of butyrate in burn injury [ 36 ]. C. butyricum and butyrate are beneficial for the homeostasis of intestinal microflora, and both decrease during burn injury and their levels were negatively correlated with gut permeability [ 36 ]: in concluding, authors have described that oral administration of C. butyricum significantly alleviated intestinal permeability.…”

Section: Reviewmentioning

confidence: 99%

“…and Shigella spp., well-known agents of bloodstream infections in burn units [ 64 , 65 ]. Gut dysbiosis seems to be strictly related to C. butyricum viability and its product butyrate, and their levels were negatively correlated with gut permeability [ 36 ]. Moreover, intestinal barrier dysfunction more exactly derives from a multifactorial complex in which other factors should be considered for a holistic, therapeutic approach, as assumed by He et al .…”

Section: Reviewmentioning

confidence: 99%

“…Recently, a particular focus on the role of supportive care (e.g. EN, probiotics, fluid resuscitation, antimicrobial therapies) and their link with dynamic microbiota changes have enabled us to discover gut bacteria biodiversity in severe burn patients: probiotics supplementation [ 36 ], high fluid resuscitation [ 39 ] and prompt enteral nutrition [ 37 , 38 ] may be beneficial for gut homeostasis in hospitalized patients. On the lung microbiome side, very little is currently known about airway microbiota after burn and inhalation injury.…”

Section: Reviewmentioning

confidence: 99%

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Microbiome in the setting of burn patients: implications for infections and clinical outcomes

2020

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Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in patients. The most deleterious impact of this dysfunction is the loss of the skin’s natural protective barrier. Furthermore, the risk of infection is exacerbated by protracted hospitalization, urinary catheters, endotracheal intubation, inhalation injury, arterial lines and central venous access, among other mainstays of burn care. Currently, infections comprise the leading cause of mortality after major burn injuries, which highlights the improvements observed over the last 50 years in the care provided to burn victims. The need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres, as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy microbiome. While preliminary studies are examining the variability and evolution of human and mice microbiota, both during the early and late phase burn injury, one must consider that abnormal microbiome conditions could influence the systemic inflammatory response. A better understanding of the changes in the post-burn microbiome might be useful to interpret the provenance and subsequent development of infections, as well as to come up with inferences on the prognosis of burn patients. This review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections, complications, and, ultimately, healing.

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Remodeling gut microbiota by Clostridium butyricum (C.butyricum) attenuates intestinal injury in burned mice

Cited by 14 publications

References 34 publications

Prebiotic agavin in juvenile totoaba, Totoaba macdonaldi diets, to relieve soybean meal‐induced enteritis: Growth performance, gut histology and microbiota

Prebiotic agavin in juvenile totoaba, Totoaba macdonaldi diets, to relieve soybean meal‐induced enteritis: Growth performance, gut histology and microbiota

Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota

Microbiome in the setting of burn patients: implications for infections and clinical outcomes

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