Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

Zhao, Xiao Guang; Chen, Rujing; Liu, Mei; Jiao, Feng; Chen, Jun; Hu, Kaili

doi:10.1016/j.apsb.2017.07.002

Cited by 55 publications

(47 citation statements)

References 166 publications

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“…GSCs have stem cell‐like properties and are thought to highly contribute to the cellular heterogeneity of GBM (Lathia, Mack, Mulkearns‐Hubert, Valentim, & Rich, ). The perivascular niche is also composed of several stromal cells including microglia, astrocytes, pericytes, fibroblasts, and endothelial cells that support tumor progression (Zhao et al, ). Furthermore, these tumors are also characterized by their ability to interact with the extracellular matrix (ECM) of the brain to favor their survival (Herrera‐Perez, Voytik‐Harbin, & Rickus, ; Nakod, Kim, & Rao, ).…”

Section: Glioblastoma Interactions With the Surrounding Brain Microenmentioning

confidence: 99%

Astrocytes, the rising stars of the glioblastoma microenvironment

Brandao

Simon

Critchley

et al. 2018

Glia

141

117

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Glioblastoma (GBM) is an aggressive primary tumor, causing thousands of deaths worldwide every year. The mean survival of patients with GBM remains below 20 months despite current available therapies. GBM cells' interactions with their stromal counterparts are crucial for tumor development. Astrocytes are glial cells that comprise~50% of all brain cells and are therefore likely to establish direct contact with GBM cells. As other tumor cell types can hijack fibroblasts or immune cells to facilitate tumor growth, GBM cells can actually activate astrocytes, namely, the tumor associated astrocytes (TAAs), to promote GBM invasion in the healthy tissue. TAAs have thus been shown to be involved in GBM cells growth and limited response to radiation or chemotherapy (i.e., Temozolomide). Nevertheless, even though the interest in the cancer research community is increasing, the role of TAAs during GBM development is still overlooked.Yet, obtaining an in-depth understanding of the mechanisms by which TAAs influence GBM progression might lead to the development of new therapeutic strategies. This article therefore reports the different levels of GBM progression at which TAAs have been recently described to be involved in, including tumor cells' proliferation/invasion and resistance to therapies, especially through the activity of extracellular vesicles. K E Y W O R D S brain, glioblastoma, stromal cells, tumor associated astrocytes, tumor microenvironment

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Section: Glioblastoma Interactions With the Surrounding Brain Microenmentioning

confidence: 99%

Astrocytes, the rising stars of the glioblastoma microenvironment

Brandao

Simon

Critchley

et al. 2018

Glia

141

117

View full text Add to dashboard Cite

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“…The pivotal roles of TME during tumor initiation, progression, and metastasis have been recently reviewed in detail elsewhere 1 , 2 . Importantly, TME greatly influences therapeutic efficacy and emerges as a new target for treating tumors 3 , 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment

Lü

et al. 2019

Acta Pharmaceutica Sinica B

113

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Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components. Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, we summarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent.

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“…Changes in the phosphorylation state of the tight junction protein (ZO-1 or occluding) are critical to the control of BBB vascular permeability. In areas of tumor environment, the endothelial cells connection is very loose and almost lacks integrity [14]. Endothelial hyperplasia is a frequent finding in glioblastoma and it is connected with an increase in nonselective transport through the BBB [15].…”

Section: Discussionmentioning

confidence: 99%

The influence of endothelial hyperplasia on pseudoprogression development in patients with glioblastoma

et al. 2019

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Introduction/Objective Pseudoprogression represents an enlarging contrast-enhancing lesion that occurs after chemoradiation and stabilizes with time without any changes in the therapeutic procedure. This phenomenon is highly significant, because it can have influence on further therapeutic procedures; however, precise criteria for pseudoprogression diagnosis have not yet been defined. The main goal of this study is to examine the endothelial hyperplasia influence on pseudoprogression. Methods We analyzed a group of 106 patients with glioblastoma who had undergone surgical treatment from 2010-2012, at the Clinic of Neurosurgery, Clinical Center of Serbia, who received Stupp protocol. Pre-and post-treatment imaging was evaluated using RANO criteria. Lesions that improved or stabilized were defined as pseudoprogression, and lesions that progressed were defined as true progression. Endothelial hyperplasia was identified based on the hematoxylin and eosin pathohistological examination. Results Thirty-two (30.2%) of the patients were diagnosed with pseudoprogression. Endothelial hyperplasia was observed in 51 (48.1%) of glioblastoma tissue samples, and 28 (87.5%) of all the patients with pseudoprogression were found to have endothelial hyperplasia. The group of 51 (68.9%) patients without pseudoprogression did not show the presence of endothelial hyperplasia. Statistical analysis showed significantly higher incidence of pseudoprogression in patients with endothelial hyperplasia. (χ 2 = 26.269, p < 0.01) Conclusion Taking into account that there are no precise diagnostic methods that could determine the presence of endothelial hyperplasia with certainty, it could be an indicator, as a pathohistological entity, of a higher likelihood of pseudoprogression, which could be used in everyday clinical practice. In order to reach definite conclusions, we believe it is necessary to conduct prospective controlled studies with larger sample sizes.

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Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

Cited by 55 publications

References 166 publications

Astrocytes, the rising stars of the glioblastoma microenvironment

Astrocytes, the rising stars of the glioblastoma microenvironment

Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment

The influence of endothelial hyperplasia on pseudoprogression development in patients with glioblastoma

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