Remote and local control of stimuli responsive materials for therapeutic applications

Chan, Alexander K.C.; Orme, Rowan; Fricker, Rosemary A.; Roach, Paul

doi:10.1016/j.addr.2012.07.007

Cited by 173 publications

(113 citation statements)

References 197 publications

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“…Biologically informed advancements in chemistry have made available stimuli responsive polymers that can controllably react to environmental stimuli, such as temperature, pH, enzymes, affinity ligands, oxidative stress, magnetic / electric fields, mechanical loading [236,237] and release their cargo. Matrix metalloproteinase (MMP) [238][239][240] or mechanical stimuli [241] responsive polymers are expected to pioneer tendon therapies in the years to come due to their sensitivity / specificity to the local tissue microenvironment.…”

Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

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Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

View full text Add to dashboard Cite

“…As one of the most important intracellular nuclear factors involving in the inflammation, NF-κB modulates the expression of various genes during the early stages of the immune response and during all stages of inflammatory response, thereby participating in immunoreaction, inflammatory response, cell apoptosis and tumor pathogenesis (O'Hare et al, 2010). Studies have revealed critical modulatory functions of ICAM-1, NF-κB, and MCP-1 in inflammatory response induced by multiple distinct factors (Chan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Role of inflammatory responses in the pathogenesis of human cerebral aneurysm

Fan¹,

Zhao²,

Yu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We aimed to detect expressional profiles of intracellular cell adhesion molecule-1 (ICAM-1), nuclear factor-kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) in human cerebral aneurysm, in order to investigate the effect of chronic inflammation on the pathogenesis of cerebral aneurysm. Samples from 40 cases of human cerebral aneurysms diagnosed at our hospital were selected along with 20 normal cerebral artery samples. Western blotting and immunohistochemical (IHC) staining were used to reveal expressional profiles of ICAM-1 and NF-κB in the aneurysmal wall of patients and normal cerebral artery tissues. Reverse transcription (RT)-PCR was employed to detect changes in transcript levels of MCP-1 mRNA. Western blotting showed significantly higher expressions of ICAM-1 and NF-κB in patients with cerebral aneurysm compared to the normal group (P < 0.01), which was consistent with IHC staining results. RT-PCR revealed significantly higher MCP-1 transcripts in cerebral 9063Inflammation and cerebral aneurysm ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9062-9070 (2015) aneurysm tissues compared to the normal group (P < 0.01), in addition to a positive relationship between ICAM-1 and NF-κB expression levels. In conclusion, expression levels of ICAM-1, NF-κB, and MCP-1 in patients are significantly elevated, suggesting an enhanced chronic inflammatory response and a significant correlation between inflammatory factors/adhesion molecules and the pathogenesis of cerebral aneurysm.

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“…At present, the management of cerebral aneurysms includes medical and surgical treatment. Medical treatment is mainly used to treat un-ruptured aneurysms by relieving the stimulation to the aneurysm wall through controlling the risk factors associated with the pathogenesis of cerebral aneurysms (Chan et al, 2013). Surgical treatment is a direct action on the cerebral aneurysm through medical devices, including clipping or ligation of the aneurysm neck, isolation of the aneurysm, and packing of the aneurysm wall.…”

Section: Discussionmentioning

confidence: 99%

Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm

et al. 2015

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ABSTRACT. We sought to investigate the relationship between abnormal expression of nitric oxide synthase (NOS) and pathogenesis of cerebral aneurysm. Brain tissues were collected from 36 patients with cerebral aneurysm confirmed by computer tomography with angiography or neurosurgical therapy. The control group consisted of 25 patients of similar age who had no vascular diseases, as confirmed by magnetic resonance imaging. Samples of cortical arterioles were collected. The structure of the aneurysms was detected by hematoxylin and eosin staining, and the expression of inducible NOS was detected by immunohistochemistry. NOS expression was significantly higher in the patient group than in the control group (patients: 30/36 strongly positive; control: 0/25 strongly positive; P < 0.05). In conclusion, the pathogenesis underlying cerebral aneurysm may be due to abnormal expression of NOS, degradation of the extracellular matrix, aggravation of a pro-inflammatory reaction, or a deficiency in arterial elasticity 4277 NOS and pathogenesis of cerebral aneurysm ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4276-4281 (2015) layer synthesis. These changes may result in a deficiency in vascular remodeling.

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Remote and local control of stimuli responsive materials for therapeutic applications

Cited by 173 publications

References 197 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Role of inflammatory responses in the pathogenesis of human cerebral aneurysm

Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm

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