Remote Assessment in healthcare—Technologies, methods, benefits, and challenges

Bardram, Jakob E.

doi:10.1371/journal.pone.0283945

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…During the COVID-19 pandemic, many clinical trials were forced to rapidly move to telemedicine follow-up of subjects with concomitant uncertainty of ability to reliably execute clinical outcome metrics. 6 Now, there is increasing acceptance of telemedicine with benefits of increased access, patient convenience, and closer follow-up of complex patients. An often-overlooked advantage of video visits, compared to in-person visits, is the recording of examinations to generate digital data sets, which are archivable for detailed analysis.…”

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confidence: 99%

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score

Garbey,

Lesport,

Girma

et al. 2024

Preprint

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Introduction: The increasing utilization of telemedicine offers an opportunity of video-recording to then perform post-hoc quantitative analysis of all aspects of the patient-examiner interaction. Presently, telemedicine examinations are adapted from the standard clinical visit, but their benefits and deficiencies have not been rigorously assessed. Methods: We utilized a bank of 54 subjects with myasthenia gravis (MG) each having two telemedicine examinations by neuromuscular experts with recording of the MG Core Examination and the MG Activities of Daily Living. We then applied a broad spectrum of artificial intelligence algorithms from computer vision and speech analysis to natural language processing to generate quantitative metrics of the digital records. Results: We successfully developed a technology to assess video examinations. Although the overall MG-CE examination scores were consistent across examiners, individual metrics showed significant variability, with up to a 25 percent variation in scoring within the MG-CE's range. There was wide range of compliance with MG ADL instructions across examiners. Discussion: We are able perform digital analysis of neuromuscular examinations and identified variations in outcome measure variations based on the examiner's instructions, video recording limitations, and the severity of the patient's disease. Particularly noteworthy is the high standard deviation in scores for examinations of patients with low disease severity.

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confidence: 99%

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score

Garbey,

Lesport,

Girma

et al. 2024

Preprint

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A 40‐week phase 2B randomized, multicenter, double‐blind, placebo‐controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis

Bhai,

Levine,

Moore

et al. 2024

Muscle and Nerve

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IntroductionAmyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no known cure, limited treatment options with minimal benefits, and significant unmet need for disease modifying therapies.AimsThis study investigated memantine's impact on ALS progression, with an additional focus on the effects of memantine on cognitive and behavioral changes associated with the disease.MethodsA randomized, double‐blind, placebo‐controlled clinical trial was conducted from December 2018 to September 2020. ALS patients were enrolled in‐person and remotely across 13 sites in the United States. Participants were randomized to memantine (20 mg twice daily) or placebo in a 2:1 ratio and completed 36 weeks of treatment. The primary outcome of disease progression was assessed by the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS‐R), and blood was collected for biomarker analysis.ResultsOf the 99 participants enrolled in the study, 89 were randomized to memantine or placebo (ages 24–83 years, male‐to‐female ratio ~3:2). Fifty‐two participants completed the study treatment with no significant differences in disease progression, biomarker changes (including neurofilament light chain [NfL]), or neuropsychiatric testing noted between the groups. Initial NfL values correlated with the rate of ALSFRS‐R decline.DiscussionIn this study, memantine did not impact ALS disease progression or neuropsychiatric symptoms. Trials with remote enrollment may help trial participation and success.

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An Initial Psychometric Evaluation of a Novel Upper Extremity Pediatric Stroke Hemiplegic Motor Impairment Scale

Malone,

Andrejow,

Naber

et al. 2024

Pediatric Neurology

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Remote Assessment in healthcare—Technologies, methods, benefits, and challenges

Cited by 5 publications

References 10 publications

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score

A 40‐week phase 2B randomized, multicenter, double‐blind, placebo‐controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis

An Initial Psychometric Evaluation of a Novel Upper Extremity Pediatric Stroke Hemiplegic Motor Impairment Scale

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