Remote Ischemic Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury after Hemorrhagic Shock by Increasing Autophagy

Zhou, Hai-Rong; Li, Lin; Sun, Huiling; Li, Hua; Wu, Yuxuan; Zhang, Xiaomin; Zhang, Jinsong

doi:10.7150/ijms.51268

Cited by 10 publications

(13 citation statements)

References 30 publications

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“…RIPC successfully induces ischemic tolerance not only in the brain, but also in the heart [ 151 ], kidneys [ 152 ], lungs [ 153 ], and liver [ 154 ], which seems to suggest that repeated ischemic preconditioning of one artery may have induced ischemic tolerance throughout the body. How does this protective effect extend from local to other areas?…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and frontiers of preconditioning in cerebral ischemia: A bibliometric analysis

Zhang,

Zhou,

Zhao

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Research hotspots and frontiers of preconditioning in cerebral ischemia: A bibliometric analysis

Zhang,

Zhou,

Zhao

et al. 2024

Heliyon

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“…While much is yet to be understood about this phenomenon, it is undoubtedly a reality, as many works have reported quasi-unbelievable responses of the liver (and other organs as well) to remote IPC events. While the release of protective elements (what those are is still a hotly debated topic) is probably involved and can flow in the circulation, protecting distant tissues, mitochondrial-function protection in the remote tissue/organ is apparently a necessity for RIPC in the liver [ 87 , 88 , 89 , 90 , 91 ].…”

Section: Surgical Approaches In Hiri Mitochondrial Function Compromisementioning

confidence: 99%

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

Silva

Machado

Panisello‐Roselló

et al. 2022

Cells

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Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios, including liver resection and transplantation. Various studies and countless surgical events have led to the observation of a strong correlation between HIRI induced by liver transplantation and early allograft-dysfunction development. The detrimental impact of HIRI has driven the pursuit of new ways to alleviate its adverse effects. At the core of HIRI lies mitochondrial dysfunction. Various studies, from both animal models and in clinical settings, have clearly shown that mitochondrial function is severely hampered by HIRI and that its preservation or restoration is a key indicator of successful organ recovery. Several strategies have been thus implemented throughout the years, targeting mitochondrial function. This work briefly discusses some the most utilized approaches, ranging from surgical practices to pharmacological interventions and highlights how novel strategies can be investigated and implemented by intricately discussing the way mitochondrial function is affected by HIRI.

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“…Ischemia-reperfusion injury (IRI) mostly occurs in clinical, such as organ transplantation, resection, trauma, and septic, or hemorrhagic shock and leads to significant mortality. 185,186 Immune cells in the ischemia-reperfusion area release various cytokines, thereby triggering a violent inflammatory response and ultimately aggravating tissue damage. The latest research proves the γδ T17 cells play an important role in the initial stage of immune response in IRI.…”

Section: Ischemia-reperfusion Injurymentioning

confidence: 99%

The role of γδ T17 cells in cardiovascular disease

Ling

You

et al. 2022

Journal of Leukocyte Biology

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Due to the ability of γδ T cells to bridge adaptive and innate immunity, γδ T cells can respond to a variety of molecular cues and acquire the ability to induce a variety of cytokines such as IL-17 family, IFN-γ, IL-4, and IL-10. IL-17 + γδ T cells (γδ T17 cells) populations have recently received considerable interest as they are the major early source of IL-17A in many immune response models. However, the exact mechanism of γδ T17 cells is still poorly understood, especially in the context of cardiovascular disease (CVD). CVD is the leading cause of death in the world, and it tends to be younger.Here, we offer a review of the cardiovascular inflammatory and immune functions of γδ T17 cells in order to understand their role in CVD, which may be the key to developing new clinical applications.

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Remote Ischemic Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury after Hemorrhagic Shock by Increasing Autophagy

Cited by 10 publications

References 30 publications

Research hotspots and frontiers of preconditioning in cerebral ischemia: A bibliometric analysis

Research hotspots and frontiers of preconditioning in cerebral ischemia: A bibliometric analysis

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

The role of γδ T17 cells in cardiovascular disease

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