BackgroundDespite its wide diffusion in surgical procedures, very few experiences are reported so far about the possible applications of remote proctoring (RP) in structural heart interventions.AimsOur aim was to demonstrate the feasibility, safety, and efficacy of RP during transcatheter edge‐to‐edge repair using a mixed reality‐based head‐mounted display (HMD).MethodsTwo users (a doctor and a proctor), wearing HMDs, were connected through a 5G network, allowing them to share audio and video signals. During the procedure, the proctor was located in a contiguous room, without any direct connection with the operator. The primary endpoint was noninferiority of HMD‐mediated interaction if compared with direct in‐person interaction. It was assessed using an operator−proctor interaction test based on six questions asked by the doctor to the proctor on six key procedural steps.ResultsBetween September 2021 and April 2022, nine patients were enrolled in the study (15 clips delivered). The primary endpoint was reached in 9/15 clips implanted (60%). The first three failures were due to a chat software problem, and the others were linked with a 5G network malfunction. However, the HMD and its mixed reality tools were well tolerated by the operators, and no interference with the procedure was registered in any of the cases.ConclusionsIn our experience, RP during structural heart interventions is feasible and efficacious. Wearing the HMD is comfortable and does not affect safety and effectiveness of interventional procedures. However, especially if considering a wide geographic use of this tool, a stable internet connection is imperative.