1986
DOI: 10.1016/0165-2478(86)90084-2
|View full text |Cite
|
Sign up to set email alerts
|

Remote-site stimulation of influenza antibodies in monkeys following intestinal stimulation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

1988
1988
2015
2015

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(3 citation statements)
references
References 6 publications
0
3
0
Order By: Relevance
“…Some improvement in vaccine responses could be elicited by inducing secondary responses with a booster immunization, even in the monkeys older than 20 years of age. Other researchers have also utilized repeat exposures to influenza virus and/or vaccine to induce more effective immune responses in monkeys (Bergman et al 1986;Rimmelzwaan et al 1997;Saslaw and Carlisle 1965). Given that many elderly humans do not mount protective responses following influenza vaccination, it may be worthwhile to consider a dual vaccine regimen for those likely to have inadequate responses.…”
Section: Discussionmentioning
confidence: 99%
“…Some improvement in vaccine responses could be elicited by inducing secondary responses with a booster immunization, even in the monkeys older than 20 years of age. Other researchers have also utilized repeat exposures to influenza virus and/or vaccine to induce more effective immune responses in monkeys (Bergman et al 1986;Rimmelzwaan et al 1997;Saslaw and Carlisle 1965). Given that many elderly humans do not mount protective responses following influenza vaccination, it may be worthwhile to consider a dual vaccine regimen for those likely to have inadequate responses.…”
Section: Discussionmentioning
confidence: 99%
“…A study of mucosal immune responses in rhesus macaques found that delivery of a killed influenza A vaccine by intraesophageal tubing elicited antibodies in the upper respiratory tract (Bergmann et al, 1986). A later report focused on the induction of mucosal immune responses to killed influenza A virus and Streptococcus mutans vaccines in the same species and found that, compared to humans, the animals mounted a weak IgA and strong IgM response to intestinal immune stimulation, suggesting that they were not a good model for researching mucosal IgA responses (Michalek et al, 1995).…”
Section: Experimental Infections Of Nhps With Human Influenza VImentioning
confidence: 99%
“…This is particularly important with respect to the oral use of inactivated microbial vaccines, which do not stimulate as strong an immune response as live at tenuated vaccines [2], The common mucosal immune system is a term used to describe the relationship between gut-asso ciated lymphoid tissue (GALT) and other mucosal surfaces and secretory glands (respiratory tract, sali vary gland, etc.) [3], Experimental and clinical studies have indicated that oral immunization is an effective way of stimulating production of respiratory tract SIgA, including those to influenza virus [4,5] sup porting evidence for the common mucosal immune system.…”
mentioning
confidence: 99%