Remotely triggered curcumin release from stimuli‐responsive magneto‐polymericlayer‐by‐layerengineered nanoplatforms

Abstract

Curcumin is a promising natural drug in cancer therapy. However, its therapeutic applicability is limited by its low solubility, short half‐life, and low bioavailability. In this work curcumin is encapsulated in stimuli‐responsive magneto‐polymeric nanoplatforms aiming at improving its bioavailability and efficiency for delivery in biological media. MnFe2O4 magnetic nanoparticles (MNPs) were synthesized via thermal decomposition, coated with sodium citrate and then functionalized with multilayers of chitosan and sodium alginate, by means of the layer‐by‐layer deposition technique. A mesoporous polymeric‐magnetic nanoplatform was produced capable of a controlled and sustained release of curcumin under temperature, pH and alternating magnetic field (magnetic hyperthermia) stimuli. As the temperature and pH of the medium increased, an increase in the rate of curcumin release was observed in a two‐stage process, following the Gallagher‐Corrigan mathematical model. The use of magnetic hyperthermia resulted in a faster diffusion‐based release of curcumin. Increasing the number of polymer layers assembled on top of MNPs hinders the release of the curcumin molecules from innermost regions of the multilayers. These results show that magnetic hyperthermia provides a means for the controlled heat‐induced release of curcumin, which can lead to an enhanced therapeutic action for curcumin.

Integration of 3D Fluorescence Imaging and Luminescent Thermometry with Core–Shell Engineered NaYF4:Nd3+/Yb3+/Ho3+ Nanoparticles

“…The obtained NPs were coated with citrate molecules using a ligand exchange process. 45 For this, the precipitate was sonicated in a mixture of hexane and citric acid solution (100 mg/mL in DMSO) and the resulting NPs were centrifuged, washed with ethanol, and redispersed in ultrapure water at pH ∼7. The core−shell synthesis process was performed using a procedure analogous to that employed for synthesizing the core with the core itself serving as the seed.…”

“…The obtained NaYF 4 :NdYbHo­(7/15/3%) precipitate was collected by centrifugation and washed with cyclohexane. The obtained NPs were coated with citrate molecules using a ligand exchange process . For this, the precipitate was sonicated in a mixture of hexane and citric acid solution (100 mg/mL in DMSO) and the resulting NPs were centrifuged, washed with ethanol, and redispersed in ultrapure water at pH ∼7.…”

Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release

“…The GC model is particularly useful for predicting drug release profiles under different conditions [ 152 ]. Additionally, it can be adapted to describe dual-phased drug release [ 152 , 153 , 154 ]. The experimental data on the release of curcumin from MnFe 2 O 4 magnetic nanoparticles with multilayered CS–alginate (ALG) shells were a good fit to the GC model.…”

Synthesis and application of polyethyleneimine and polyethylene glycol grafted on CoFe2O4/single‐walled carbon nanotubes as a delivery platform for silibinin: Loading experiments, modeling, and in‐vitro release studies

“…In recent decades, research on chemotherapy has demonstrated that most of anti‐cancer drugs can somewhat restrain tumor growth; however, due to some limitations such as premature degradation and incapability of discriminating between malignant and normal cells, they cause unwanted side effects and non‐specific cytotoxicity 1 . Targeted drug therapy systems, including nanomaterials, have been known as plausible solutions to cope with the issues 2–4 …”

“…1 Targeted drug therapy systems, including nanomaterials, have been known as plausible solutions to cope with the issues. [2][3][4] It has been asserted that nanomaterials are capable of being passively accumulated in tumors because of their higher permeability and retention (EPR). A nanoscale drug delivery system has diverse benefits, including but not confined to: (1) a targeted delivery that lowers systemic exposure to a potentially harmful compound while increasing drug concentration at the intended spot; (2) a steady rate of drug delivery to sustain a continuous treatment dose at the delivery site; and (3) improved drug stability as a result of protection against degradation and loss of drugs.…”