Removal of bacteriophages with different surface charges by diverse ceramic membrane materials in pilot spiking tests

Hambsch, B.; Bösl, M.; Eberhagen, Ingrid; Müller, Uwe

doi:10.2166/wst.2012.141

Cited by 6 publications

(4 citation statements)

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“…A complex wastewater sample with variable matrix composition can be processed using customised nano-filtration membranes [278] to enrich SARS-CoV-2, which is a large, positive, non-segmented, enveloped single-strand RNA virus with a spherical, elliptical or pleomorphic form with an average diameter of 60-140 mm [279]. MS2 bacteriophage has been widely used as a surrogate for pathogenic waterborne viruses (poliovirus, hepatitis A virus and perhaps for rotavirus) [280][281][282] to test various nano-filters; it can be modified for SARS-CoV-2 retention and binding to the channels in a "Microfluidic chip". For instance, carbon nanotube filters were used to eliminate waterborne viral and bacterial pathogens.…”

Section: Next-generation Monitoring Toolsmentioning

confidence: 99%

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance

et al. 2021

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The spectrum of emerging new diseases as well as re-emerging old diseases is broadening as infectious agents evolve, adapt, and spread at enormous speeds in response to changing ecosystems. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recent phenomenon and may take a while to understand its transmission routes from less traveled territories, ranging from fomite exposure routes to wastewater transmission. The critical challenge is how to negotiate with such catastrophic pandemics in high-income countries (HICs ~20% of the global population) and low-and middle-income countries (LMICs ~ 80% of the global population) with a total global population size of approximately eight billion, where practical mass testing and tracing is only a remote possibility, particularly in low-and middle-income countries (LMICs). Keeping in mind the population distribution disparities of high-income countries (HICs) and LMICs and urbanisation trends over recent years, traditional wastewater-based surveillance such as that used to combat polio may help in addressing this challenge. The COVID-19 era differs from any previous pandemics or global health challenges in the sense that there is a great deal of curiosity within the global community to find out everything about this virus, ranging from diagnostics, potential vaccines/therapeutics, and possible routes of transmission. In this regard, the fact that the gut is the common niche for both poliovirus and SARS-CoV-2, and due to the shedding of the virus through faecal material into sewerage systems, the need for long-term wastewater surveillance and developing early warning systems for better preparedness at local and global levels is increasingly apparent. This paper aims to provide an insight into the ongoing COVID-19 crisis, how it can be managed, and what measures are required to deal with a current global international public health concern. Additionally, it shed light on the importance of using wastewater surveillance strategy as an early warning practical tool suitable for massive passive screening, as well as the urgent need for microfluidic technology as a rapid and cost-effective approach tracking SARS-CoV-2 in wastewater.

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Section: Next-generation Monitoring Toolsmentioning

confidence: 99%

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance

et al. 2021

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“…119 Filtration by tangential flow with unique membrane is explored as an alternative to traditional centrifugation method. 120 Torres-Acosta et al developed a bioprocess model, performing economic analysis of various development scenarios for phage production. 121 Future studies are required to optimize several aspects of largescale bacteriophage production, including facilities and equipment, safety issues, and cost-effectiveness.…”

Section: Difficult To Produce For Industrial Applicationmentioning

confidence: 99%

“…For example, an effective method developed for the purification of nanoparticles based on anti‐anion exchange chromatography yield a 60% recovery of viable phages 119 . Filtration by tangential flow with unique membrane is explored as an alternative to traditional centrifugation method 120 . Torres‐Acosta et al .…”

Section: Difficult To Produce For Industrial Applicationmentioning

confidence: 99%

Challenges for the application of bacteriophages as effective antibacterial agents in the food industry

Zhao

Zhan

et al. 2021

J Sci Food Agric

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Food contamination caused by foodborne pathogens is one of the most important concerns in public health worldwide, and accounts for a significant portion of food loss every year. The emergence of antimicrobial resistant bacteria has turned the attention of researchers back to the potential of bacteriophages as antibacterial agents, and their use has been attempted in various pre-and post-harvest food production settings. The application of phage-based antibacterial products has achieved considerable success but a number of technical, environmental and administrative challenges remain unaddressed. In this review, we summarize the current status of bacteriophage application in the food industry. We discuss the obstacles facing the further development of phage-based antibacterial products from the aspects of technology, environmental safety, and administrative policy. We also advance some possible solutions to these challenges.

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“…New purification alternatives are being studied, e.g., suitable methods designed for purification of bionanoparticles, based on anion-exchange chromatography, with a 60% recovery of viable phages ( Adriaenssens et al, 2012 ). Alternatives to centrifugation such as tangential flow filtration and specific membrane materials could also be explored ( Hambsch et al, 2012 ).…”

Section: Future Perspectives For Phage-based Disinfectantsmentioning

confidence: 99%

Bacteriophages as Weapons Against Bacterial Biofilms in the Food Industry

et al. 2016

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Microbiological contamination in the food industry is often attributed to the presence of biofilms in processing plants. Bacterial biofilms are complex communities of bacteria attached to a surface and surrounded by an extracellular polymeric material. Their extreme resistance to cleaning and disinfecting processes is related to a unique organization, which implies a differential bacterial growth and gene expression inside the biofilm. The impact of biofilms on health, and the economic consequences, has promoted the development of different approaches to control or remove biofilm formation. Recently, successful results in phage therapy have boosted new research in bacteriophages and phage lytic proteins for biofilm eradication. In this regard, this review examines the environmental factors that determine biofilm development in food-processing equipment. In addition, future perspectives for the use of bacteriophage-derived tools as disinfectants are discussed.

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Removal of bacteriophages with different surface charges by diverse ceramic membrane materials in pilot spiking tests

Cited by 6 publications

References 0 publications

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance

Challenges for the application of bacteriophages as effective antibacterial agents in the food industry

Bacteriophages as Weapons Against Bacterial Biofilms in the Food Industry

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