Fluoropolymers such as PFA are used as coatings for the protection of metal substrates due to their high chemical inertia and non-stick properties. These are “wear and tear” coatings and they degrade, at which point they should be removed for a new application. The removal of these types of coating by laser is of interest due to the process’s flexibility, precision, ease of automation, and environmental sustainability. The efficiency of the procedure was shown with the use of a source in a pulsed Nd:YAG and a source in continuous mode of fiber (Yb). The rates of stripping (cm2/min) and fluence (J/cm2) were analyzed and related to the power of the laser sources. Variations of the substrate after stripping were studied: roughness and hardness. The properties of the coating, thickness, roughness, water sliding angle, and microhardness were also evaluated. It was concluded that the laser in continuous mode was more efficient than the pulsed laser; laser removal of fluoropolymers has a strong relationship with reflectivity, and the mechanical and surface properties of the substrate after stripping remained virtually unchanged.