Remyelination and recovery of conduction in cat optic nerve after demyelination by pressure

Cottee, Lynne J.; Daniel, Cabrera; Loh, Wai Sim; Harrison, B.M.; Burke, William J.

doi:10.1016/s0014-4886(03)00310-8

Cited by 26 publications

(19 citation statements)

References 39 publications

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“…Secondarily, remyelination and restoration of axoplasmic flow contribute to sustained visual recovery over months and up to years [26,27,29,30]. In a model of optic nerve compression in cats, Cottee et al demonstrated remyelination that seemed to coincide with a secondary phase of conduction recovery occurring between 6 and 11 weeks after decompression [31]. Clinically, a slow but further phase of visual recovery is observed in some patients up to 3 years after surgery and the potential mechanisms for this would include ongoing remyelination and anterior visual pathway remodeling [27].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, a slow but further phase of visual recovery is observed in some patients up to 3 years after surgery and the potential mechanisms for this would include ongoing remyelination and anterior visual pathway remodeling [27]. Indeed in the cat model remyelination of the optic nerve continued to levels greater than at baseline up to about 3 months after decompression [31]. However, present studies investigating the prognostic value of RNFL thickness in optic nerve compression have used either a single post-operative time point or two within 3 months of surgery to determine visual recovery [21][22][23][24]32].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optical coherence tomography predicts visual outcome for pituitary tumors

Danesh‐Meyer¹,

Wong²,

Papchenko³

et al. 2015

Journal of Clinical Neuroscience

133

102

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography predicts visual outcome for pituitary tumors

Danesh‐Meyer¹,

Wong²,

Papchenko³

et al. 2015

Journal of Clinical Neuroscience

133

102

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“…One view is that improvement of secondary processes such as microtubule reorganization, axonal swelling, and ion channel permeability is responsible for early visual recovery (14, 15). Another view is that remyelination plays a significant role in supporting rapid recovery of visual abilities (13).…”

Section: Introductionmentioning

confidence: 99%

White matter changes linked to visual recovery after nerve decompression

et al. 2014

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The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. Here we use a model of reversible white matter injury, compression of the optic chiasm by tumors of the pituitary gland, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical tumor removal and subsequent decompression of the nerves. We show that compression of the optic chiasm leads to demyelination of the optic tracts, which reverses as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicts visual ability and functional activity in early cortical visual areas, and pre-operative measurements of myelination in the optic tracts predicts the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a significant component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the utility of diffusion tensor imaging as an in vivo measure of myelination in the human brain.

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“…At this time remyelination was present. 15 It is possible that similar processes are occurring in abducens nerve fibres subject to extrinsic compression. The rarity of the presentation of remission of sixth nerve palsy in the presence of compression may reflect the slow-growing nature of the types of tumours reported to cause this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier’s Disease

Raoof

Batty

Carroll

et al. 2015

Neuro-Ophthalmology

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Relapsing-remitting sixth nerve palsy is usually due to ophthalmoplegic migraine (recurrent cranial nerve palsy) in younger patients and microvascular disease in older patients. There have been isolated reports, however, of it occurring in the presence of a skull base tumour. We report a 20-year-old woman with Ollier's disease who presented with a relapsing-remitting sixth nerve palsy. Neuro-imaging revealed a skull base enchondroma.

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Remyelination and recovery of conduction in cat optic nerve after demyelination by pressure

Cited by 26 publications

References 39 publications

Optical coherence tomography predicts visual outcome for pituitary tumors

Optical coherence tomography predicts visual outcome for pituitary tumors

White matter changes linked to visual recovery after nerve decompression

Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier’s Disease

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