Renal and Hepatic Disease:<i>Cnidoscolus aconitifolius</i>as Diet Therapy Proposal for Prevention and Treatment

Valdez, María Lilibeth Manzanilla

doi:10.1080/07315724.2020.1810171

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…Regarding the liver, our combination demonstrated a hepatoprotective effect by significantly decreasing the serum level of transaminase, malondialdehyde, and alkaline phosphatase and significantly increasing the serum level of total proteins. These results can be attributed to bioactive compounds such as phenols that can help in the recovery from hepatic cell injuries because of diabetes by regulating alterations in liver enzymes and protecting cell membrane permeability or avoiding liver cell rupture [37]. These results are similar to those obtained by Rajangam et al [38].…”

Section: Discussionsupporting

confidence: 84%

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats

Tekou,

Woumbo,

Kemtsop

et al. 2023

Cureus

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BackgroundMany plants are used to reduce the side effects of diabetes mellitus. These plants (including Vernonia amygdalina and Tamarindus indica) are rich in phytochemical compounds that have the ability to reduce glycemia and the effect of diabetes-related oxidative stress. In this study, we aimed to investigate the antioxidant and antidiabetic activities of combining V. amygdalina leaves and T. indica pulp extracts. MethodologyWe prepared a mixture by combining V. amygdalina leaves and T. indica pulp extracts, and we assessed antioxidant properties via the capacity of both extracts to reduce ferric ions, 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals, and hydroxyl radicals. We also assessed antidiabetic properties through the capacity of the extracts' combination to inhibit alpha-amylase. We evaluated crude fiber, total phenols content (TPC), and total flavonoid content (TFC). ResultsFrom our findings, the combination at a concentration of 200 μg/mgE showed that a percentage of 55.17±1.2 could reduce DPPH radicals, 0.366±0.012 could scavenge ferric ions, and 0.233±0.0022 could reduce hydroxyl radicals. With regard to secondary metabolites, we obtained 16.96±0.17 mEGA/gE for total phenol content, 1.74±0.045 mECAT/gE for total flavonoid content, and crude fiber content in our combination at 6.87±1%. These results were obtained with a significant difference at the 5% threshold. The extract combination also showed an alpha-amylase inhibitory percentage of 23.56±4.6% at the concentration of 200 μg/mgE. Daily administration of the combination of extracts significantly lowered the fasting blood glucose, triglycerides, total cholesterol, LDL cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, and malondialdehyde. However, there was a significant increase in serum proteins and HDL cholesterol. We did not observe an antagonistic effect between our combination and glybenclamide. ConclusionOur formulation, therefore, presents antioxidant and antidiabetic activity and could be used for the management of diabetic patients.

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Section: Discussionsupporting

confidence: 84%

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats

Tekou,

Woumbo,

Kemtsop

et al. 2023

Cureus

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“…These compounds are biologically active and can prevent or treat diseases. Several studies in animal models have evaluated their biological effects against various conditions, revealing antidiabetic [98], antithrombotic [99], hepatoprotective [100], nephroprotective [100], anti-inflammatory [101], and antioxidant [101] effects.…”

Section: Cnidoscolus Aconitifolius (Mill) Im Johnstmentioning

confidence: 99%

Antioxidant Potential and Known Secondary Metabolites of Rare or Underutilized Plants of Yucatan Region

Uuh-Narvaez,

Segura-Campos,

Sytar

2023

Future Pharmacology

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The screening of rare plants from the Yucatan region and the known native plants in Mexico, that have been successfully introduced worldwide, has been conducted. Based on a literature analysis and a search of English and Spanish scientific information regarding botanical, plant biochemical, and antioxidant potential in databases such as Google Scholar, Scopus, Web of Knowledge, as well as the national databases of Mexico (Flora: Yucatan Peninsula (cicy.mx) and Especies endémicas|Biodiversidad Mexicana), rare or underutilized plants from the Yucatan region with antioxidant potential have been selected. The formulas of the most studied secondary metabolites of these selected rare plants are shown. Among the selected rare plants with antioxidant potential, the families Sapidaceae and Anacardiaceae had the highest number of representatives. Additionally, representatives from the families Annonaceae, Moraceae, Malpighiaceae, Solanaceae, Ebenaceae, Asteraceae, Ranunculaceae, and Leguminosae were also presented. The current scientific data analysis of selected rare plants from the Yucatan region, Mexico, provides significant background for their further use and introduction in not only the Yucatan region of Mexico, but also worldwide.

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“…However, oxidative stress and pro‐inflammatory cytokines that contribute to the pathogenesis of T2DM affect its functions. Evidence has shown hepatic alterations, such as abnormal glycogen synthesis, fibrosis, cirrhosis, acute liver disease, and hepatic hepatitis in patients with T2DM (Manzanilla‐Valdez & Segura‐Campos, 2020; Mohamed et al., 2016). Diabetic nephropathy is one of the most common complications in T2DM and is the principal cause of end‐stage renal disease.…”

Section: Brief Overview Of the Development Of T2dmmentioning

confidence: 99%

“…Renal problems are associated with impaired glycemic control induced by oxidative stress, hypertension, hypertriglyceridemia, and inflammation, resulting in direct damage to glomerular and epithelial cells of the kidneys during T2DM. Likewise, increased ROS production in diabetic conditions has been associated with vasoconstriction, endothelial dysfunction, modification of extracellular matrix proteins, and increased renal sodium reabsorption (Elmarakby & Sullivan, 2012; Manzanilla Valdez & Segura Campos, 2020).…”

Section: Brief Overview Of the Development Of T2dmmentioning

confidence: 99%

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

Narvaez

Campos

2021

Journal of Food Science

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Type 2 diabetes mellitus (T2DM) is increasing the prevalence worldwide at an alarming rate, becoming a serious public health problem that mainly affects developing countries. Functional food research is currently of great interest because it contributes to developing nutritional therapy strategies for T2DM prevention and treatment. Bioactive compounds identified in some plant foods contribute to human health by mechanisms of action that exert biological effects on metabolic pathways involved in the development of T2DM. Hence, vegetables with high bioactive compounds content may be a source of functional value for the control of T2DM. Cabbages varieties (Brassica oleracea var. capitata) such as green (GCB), white (WCB), and red (RCB) are foods consumed (raw or cooked) and cultivated in different regions of the world. Scientific evidence shows that cabbage has multi-target effects on glucose homeostatic regulation due to its high content of bioactive compounds. It has also been shown to decrease damage to organs affected by T2DM complications, such as the liver and kidney. Additionally, it could contribute as a preventive by attenuating problems underlying the development of T2DM as oxidative stress and obesity. This review highlights the functional properties of cabbage varieties involved in glucose regulation and the main mechanisms of the action exerted by their bioactive compounds. In conclusion, cabbage is a valuable food that can be employed as part of nutritional therapy or functional ingredient aimed at the prevention and treatment of T2DM.

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Renal and Hepatic Disease:Cnidoscolus aconitifoliusas Diet Therapy Proposal for Prevention and Treatment

Cited by 4 publications

References 62 publications

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats

Antioxidant Potential and Known Secondary Metabolites of Rare or Underutilized Plants of Yucatan Region

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

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