Renal carcinoid tumor with liver metastasis followed up postoperatively for 9 years

Ouyang, BinShen; Ma, Xiaomei; Yan, Huixin; He, Jia; Xia, Chunyan; Yu, Hong‐Yu

doi:10.1186/s13000-015-0417-7

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…Well-differentiated NET of renal is a relatively low-grade malignancy, but it often occurs local invasion, lymph node and distant metastasis. In our study, seven cases (24.1%, 7/29) had local renal sinus, 16 , 20 , 21 perirenal fat and nerve invasion; eight cases (27.6%, 8/29) had lymph nodes metastasis; 6 , 16 , 17 , 21 , 27 and nine cases (31%, 9/29) had distant metastasis, 6 , 7 , 13 , 14 , 16 , 21 , 22 , 25 , 26 including five (17.2%, 5/29) cases of liver metastasis 6 , 7 , 14 , 16 , 26 and three cases (10.3%, 3/29) of lung metastasis. 6 , 21 , 25 In addition, the tumor can metastasize to bone, 6 contralateral kidney and adrenal, 13 eye, 14 pancreas, 21 , 25 thyroid, skin, 13 renal vein and inferior vena cava.…”

Section: Discussionsupporting

confidence: 47%

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Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

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Primary carcinoid tumor of the kidney is an extremely rare well-differentiated neuroendocrine tumor, which is generally a low-grade malignant cancer with a good prognosis. Carcinoid tumors are rarely found in the urinary system. Here, we report a 34-year-old woman with primary renal well-differentiated neuroendocrine tumor who underwent nephron sparing surgery and no evidence of recurrence or distant metastasis was found during routine follow-up. We searched the case of renal carcinoid with the search phrase “carcinoid [title] and kidney [title]” and “carcinoid [title] and renal [title]” using the PubMed and restricted the search to articles published in English since 2013. The clinical manifestations, age, sex, tumor size, location, gross pathology, light microscopy and immunohistochemistry were analyzed. A total of 28 cases of renal carcinoid were retrieved from PubMed. Higher proportion of positive labeling of CgA, Syn, NSE and CD56 are most valuable in the diagnosis of primary renal well-differentiated neuroendocrine tumor. At present, radical nephrectomy remains the gold standard in the curative-intent therapy for well-differentiated neuroendocrine carcinoma of kidney, in metastatic renal carcinoid, long-term use of octreotide may be an effective adjuvant therapy.

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Section: Discussionsupporting

confidence: 47%

“…In metastatic carcinoid tumor of kidney, long-term use of octreotide was reported, and octreotide showed a good clinical effect. 7 , 14 , 16 …”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

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“…Primary well‐differentiated renal NET (hereafter referred to as renal NET) is rare, with ~100 cases reported in the literature, mainly as case reports or small series (the largest original study described 21 tumours) …”

Section: Introductionmentioning

confidence: 99%

Primary renal well‐differentiated neuroendocrine tumour (carcinoid): next‐generation sequencing study of 11 cases

et al. 2019

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Aims Primary renal well‐differentiated neuroendocrine tumour (NET) (hereafter referred to as renal NET) is rare, with ~100 cases having been reported in the literature. There are also limited data on the molecular–genetic background of primary renal NETs. Methods and results We analysed 11 renal NETs by using next‐generation sequencing (NGS) to identify characteristic genetic aberrations. All tumours were positive for synaptophysin, and also expressed insulinoma‐associated protein 1 (10/11), chromogranin‐A (8/11), and CD56 (3/11). Cytoplasmic positivity of CD99 was present in eight of 11 cases, and strong nuclear expression of α‐thalassaemia/mental retardation syndrome X‐linked (ATRX) was retained in all 11 cases. Molecular–genetic analysis of aberration of VHL gave negative results in all cases. Loss of heterozygosity on chromosome 3p21 was found in three of nine analysable cases. NGS was successful in nine cases, showing a total of 56 variants being left after the updated filtering process, representing an average of five variants per sample. All analysable cases were negative for ATRX and DAXX (death‐domain associated protein X) mutations. The most frequently mutated genes were CDH1 and TET2, with three mutations in two cases. Mutations in AKT3, ROS1, PIK3R2, BCR and MYC were found in two cases. The remaining 41 genes were found to be mutated only in individual cases. In four cases, the mutations affected a subset of genes related to angiogenesis. Conclusions Overall, the mutation profile of primary renal NETs is variable, and none of the studied genes or affected pathways seems to be specific for renal NET.

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“…14 Very few reports have shown metastasis with long-term follow-up. 10, 11, 18, 19 As most of the literature shows small case series, the management and prognosis are unclear. The primary treatment of localized renal neuroendocrine tumors is excision either radical or partial nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Primary Renal Well-Differentiated Neuroendocrine Tumors: Analyis of Six Cases from a Tertiary Care Center in North India with Review of Literature

et al. 2022

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Well-differentiated renal neuroendocrine tumors are rare tumors. As their biologic behavior is not fully known, there is a need to know more about these cases. We performed a retrospective chart review of all the cases diagnosed with renal neuroendocrine tumors from January 2016 to December 2020 (five years) in order to understand their clinical features, morphological characteristics and outcome. We included six cases with mean age of 46.2 years (4 males) in our study. All patients underwent radical nephrectomy. Histologically all showed tumor disposed in nests and trabeculae and majority of the tumors belonged to well-differentiated neuroendocrine tumor Grade 1 (WHO criteria of gastoroenteropancreatic neuroendocrine neoplasms). Lymph node metastasis was seen in two cases at the time of clinical presentation. All the tumors were diffusely positive for neuroendocrine tumor markers (synaptophysin, chromogranin, NSE, CD56). Follow-up data was available in all cases with an average follow-up of two years and neither has shown evidence of metastasis or relapse till last follow-up. Role of morphological patterns and immunohistochemical markers is highlighted with the importance of including Ki-67 index in grading them to better understand their outcome.

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Renal carcinoid tumor with liver metastasis followed up postoperatively for 9 years

Cited by 6 publications

References 16 publications

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Primary renal well‐differentiated neuroendocrine tumour (carcinoid): next‐generation sequencing study of 11 cases

Primary Renal Well-Differentiated Neuroendocrine Tumors: Analyis of Six Cases from a Tertiary Care Center in North India with Review of Literature

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