Renal cell carcinoma and amyopathic dermatomyositis

Abstract

Amyopathic dermatomyositis (dermatomyositis siné myositis) is a rare disorder with cutaneous lesions identical to those of classic dermatomyositis, but with no clinical evidence of myopathy. Association with malignancy has been suggested in a number of reports. We report the case of a 69-year-old man with a recent diagnosis of amyopathic dermatomyositis, who presented to the urology service with hematuria. Investigations revealed a 5.8-cm renal cell carcinoma and the patient underwent left radical nephrectomy without complication. To our knowledge, an association with renal cell carcinoma and amyopathic dermatomyositis has not been previously described.

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

“…Idiopathic inflammatory myopathies include conditions such as dermatomyositis, polymyositis, sporadic inclusion body myositis, and immune-mediated necrotizing myopathy [103,104]. These idiopathic inflammatory myopathies, characterized by muscle weakness, pain, and rash, are sometimes associated with an underlying malignancy and are described as paraneoplastic syndromes [105]. Renal tumors have been rarely identified in dermatomyositis and have been published as case reports [103,[105][106][107][108].…”

“…These idiopathic inflammatory myopathies, characterized by muscle weakness, pain, and rash, are sometimes associated with an underlying malignancy and are described as paraneoplastic syndromes [105]. Renal tumors have been rarely identified in dermatomyositis and have been published as case reports [103,[105][106][107][108]. A brief analysis of these reports (five cases) highlighted: an average age over 60 years, a male-to-female ratio of 2:3, the presence of urinary symptoms in only one case, a diagnosis of a paraneoplastic condition that preceded detection of advanced-stage RCC, vulnerability to infections caused by immunosuppressive therapy applied, and abnormalities in serum muscle enzymes (creatine kinase, aldolase) [103,[105][106][107][108].…”

“…Renal tumors have been rarely identified in dermatomyositis and have been published as case reports [103,[105][106][107][108]. A brief analysis of these reports (five cases) highlighted: an average age over 60 years, a male-to-female ratio of 2:3, the presence of urinary symptoms in only one case, a diagnosis of a paraneoplastic condition that preceded detection of advanced-stage RCC, vulnerability to infections caused by immunosuppressive therapy applied, and abnormalities in serum muscle enzymes (creatine kinase, aldolase) [103,[105][106][107][108]. An occasional event is amyopathic dermatomyositis, reported in a patient with RCC presenting with hematuria [105].…”

Dermatomiositis amiopática como primera manifestación de cáncer de uréter

“…(1) Otros casos de malignidad urológica asociada a DM más frecuentes que el carcinoma ureteral han sido reportados, como cáncer de próstata, (8) testículo, (10) vejiga, (6,9) y riñón. (7,11) un varón de 69 años con DMA y carcinoma de células renales, en el que mejoraron las lesiones cutáneas y sin evidencia posterior de malignidad tras cirugía de nefrectomía radical. (11) Este caso demuestra que la DMA puede ser una manifestación precoz y única del cáncer ureteral, por lo que es importante realizar un tamizaje de cáncer en pacientes que cursan con DM.…”

“…(7,11) un varón de 69 años con DMA y carcinoma de células renales, en el que mejoraron las lesiones cutáneas y sin evidencia posterior de malignidad tras cirugía de nefrectomía radical. (11) Este caso demuestra que la DMA puede ser una manifestación precoz y única del cáncer ureteral, por lo que es importante realizar un tamizaje de cáncer en pacientes que cursan con DM.…”