Renal Cell Carcinoma Detected on Tc-99m-Labeled Red Blood Cell Imaging

Cortés, Julia Tamara Álvarez; Alonso, J.; Ruiz-Oliva, Francisco; Álvarez, S. Gallana; Ormijana, Julio Saenz; Catón, B.; Alcorta, P.

doi:10.1097/01.rlu.0000093089.53875.3e

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…Nonenteric bleeding activity can move and accumulate and confuse interpretation, including intraperitoneal hemorrhage (108,109), mesenteric bleeding (110), and soft-tissue hematoma/hemorrhage (111)(112)(113)(114)(115)(116). Both benign and malignant neoplasms and metastatic disease can cause hyperemia and bleeding when ulcerated or necrotic (117)(118)(119)(120)(121)(122)(123)(124)(125)(126). Retroperitoneal bleeding can show focal uptake that grows in intensity but is not expected to move in a luminal pattern (127).…”

Section: Increased Rbc Activity Due To Other Causesmentioning

confidence: 99%

The SNMMI Procedure Standard/EANM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 2.0

Dam

Brandon

Grantham

et al. 2014

Journal of Nuclear Medicine Technology

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Section: Increased Rbc Activity Due To Other Causesmentioning

confidence: 99%

The SNMMI Procedure Standard/EANM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 2.0

Dam

Brandon

Grantham

et al. 2014

Journal of Nuclear Medicine Technology

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“…99m Tc-labeled RBC scintigraphy is a very useful method for detecting active GI bleeding; previous studies have reported the sensitivity and specificity of 99m Tc-labeled RBC scintigraphy as 78.6-97 % and 70.4-100 %, respectively [4,5]. However, other studies have reported potential pitfalls, unanticipated and false-positive results, but most of them could be excluded because of untypical patterns of radioactivity [1,[4][5][6][7][8]. The present study could also rule out the possibility of GI bleeding.…”

mentioning

confidence: 99%

Inferior Vena Cava Filter Thrombus: a Possible Cause of an Unanticipated Finding of 99mTc-labeled Red Blood Cell Scintigraphy

Song

Choi

Kim

2015

Nucl Med Mol Imaging

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99m Tc-labeled red blood cell scintigraphy, a sensitive and specific diagnostic test, is useful for patients suspected of suffering from active gastrointestinal bleeding. This study follows a case of a patient who was suspected of gastrointestinal bleeding after an inferior vena cava filter was inserted due to a deep vein thrombosis of the femoral vein. To evaluate an exact focus of bleeding, 99m Tc-labeled red blood cell scintigraphy was executed. Herein, an unanticipated finding of 99m Tc-labeled red blood cell scintigraphy probably due to a thrombus on the inferior vena cava filter is reported.Keywords Deep vein thrombosis . Red blood cells . Scintigraphy . Gastrointestinal . BleedingIn November 2014, an inferior vena cava (IVC) filter was inserted in a 64-year-old male because of deep vein thrombosis of the right common femoral vein. He was prescribed 2 mg to 5 mg warfarin to prevent thrombosis from developing. After 2 weeks of taking warfarin, he complained of hematochezia. His hemoglobin levels were 70-90 g/l; gastrointestinal (GI) bleeding was suspected, and warfarin treatment was ceased. Computed tomography (CT) angiography, capsule endoscopy, gastroscopy and colonoscopy were performed, but the tests showed no specific areas of active bleeding. However, they did find ulcers in the cecal area. To identify the focus of the bleeding, 99m Tc-labeled red blood cell (RBC) scintigraphy was executed, and a modified in vitro method was used for RBC labeling. Focal radioactivity appeared in the mid-abdomen area on the 50-min image, remained with no interval change for 4 h, then disappeared on the 21-h image (Fig. 1a). Since this was not a typical pattern of GI bleeding (initial focal activity, increasing activity with time and focus moving in a pattern corresponding to the lumen), GI bleeding could be ruled out [1]. The CT angiography performed 3 days earlier was reviewed retrospectively. The CT angiography showed that an IVC filter existed at the same location as where focal radioactivity appeared in the 99m Tc-labeled RBC scintigraphy (Fig. 1b, c; empty arrows). The authors postulated that a thrombus developed after the injection of 99m Tc-labeled RBC and was caught by the IVC filter because of warfarin management, which had been withdrawn 1 week before, and RBCs were considered to be involved in venous thrombi via passive trapping [2]. It is supposed that the thrombus, located in a lower extremity, rose to the inferior vena cava area after the 40-min image. A possible cause of the disappeared radioactivity on the 21-h image is the thrombus dropping down from the IVC filter after the 4-h image [3]. Consequently, physicians could not find the focus of the bleeding and suspected ulcers of the cecal area. After conservative management, including RBC transfusion, the patient's hemoglobin levels returned to normal. 99m Tc-labeled RBC scintigraphy is a very useful method for detecting active GI bleeding; previous studies have reported the sensitivity and specificity of 99m Tc-labeled RBC scintigraphy as 78.6-...

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“…These radiopharmaceuticals can be used for important applications, including imaging of cardiovascular system (Niemeyer et al, 1995;Crandall et al, 2008;Javadi et al, 2011), peripheral arterial blood flow (Blond and Madsen, 2000;Harel et al, 2005;Hsieh et al, 2009), evaluation of gastrointestinal bleeding (Zaman et al, 2004;Wong et al, 2004;Olds et al, 2005;Schillaci et al, 2009;Dolezal et al, 2011), measurement of red cell volume (Hladik III et al, 1987), hepatic hemangiomas (Artiko et al, 2004;Verdu et al, 2005;Yarlagadda et al, 2008), renal carcinoma (Cortes et al, 2003), splenic reticuloendothelial system (Jin et al, 2004;Slart et al, 2004) and imaging infection (Stoeckli et al, 1996) Tc to internal structures (Early and Soddee, 1995;Dewanjee et al, 1982). The band-3 anion transport system and calcium channels may be involved in transport of 99m TcO 4 -and Sn…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biologic effects of an Ilex paraguariensis aqueous extract on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

Braga¹,

Gomes²,

Santos³

et al. 2013

Afr. J. Pharm. Pharmacol.

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Ilex paraguariensis (mate-tea) has been used to treat type-2 diabetes and emphysema. This tea presents antioxidant activity and promotes satiety, body weight lowering and improves bone mineral density. Blood constituents have been labeled with technetium-99m ( 99m Tc) and this labeling depends on the presence of a reducing agent. Stannous chloride has been widely utilized with this purpose. The influence of natural and synthetic drugs in this procedure has been reported. It was evaluated with effect of an aqueous mate-tea extract on the labeling of blood constituents with 99m Tc and on the morphology of erythrocyte. Blood samples of Wistar rats were incubated with mate-tea extract, stannous chloride and 99m Tc-sodium pertechnetate. Blood cells (BC) and plasma (P) were isolated. BC and P were also precipitated and soluble (SF) and insoluble (IF) fractions separated. The radioactivity was counted and percentage of incorporated radioactivity (%ATI) determined. Blood smears were performed for morphological evaluation. The data show a significant (p < 0.05) alteration of %ATI in BC, IF-C and IF-P as well as on the erythrocyte morphology. These findings could be related to the redox properties of the substances of the mate-tea extract, as well as due to the interference in the transport of stannous and/pertechnetate into the BC due to the morphological alterations of the erythrocytes.

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Renal Cell Carcinoma Detected on Tc-99m-Labeled Red Blood Cell Imaging

Cited by 11 publications

References 5 publications

The SNMMI Procedure Standard/EANM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 2.0

The SNMMI Procedure Standard/EANM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 2.0

Inferior Vena Cava Filter Thrombus: a Possible Cause of an Unanticipated Finding of 99mTc-labeled Red Blood Cell Scintigraphy

Evaluation of biologic effects of an Ilex paraguariensis aqueous extract on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

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