Renal cell carcinoma of native kidneys in renal transplant recipients

Ishikawa, Nobuo; Tanabe, Kazunari; Tokumoto, Tadahiko; Koga, Shoji; Okuda, Hisashi; Nakazawa, Hayakazu; Takahashi, Kota; Toma, Hiroshi

doi:10.1016/s0041-1345(98)00975-0

Cited by 17 publications

(12 citation statements)

References 4 publications

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“…Although renal papillary carcinoma comprises 25%-40% of the histologic subtypes seen in transplantation patients ( 6,(23)(24)(25)(26), compared with the 10%-15% of these subtypes seen in the general population ( 6 ), this incidence reached 85% (17 of 20) of the solid tumors in our series. While the cause of this phenomenon is not fully understood, the higher incidence of papillary carcinoma may be due to the prior long-term dialysis that many of these patients have received ( 6 ).…”

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 56%

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Cornelis

Buy²,

André³

et al. 2011

Radiology

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Purpose:To retrospectively evaluate the midterm outcome of patients treated for primary renal cell carcinomas arising in kidney transplants with minimally invasive techniques. Materials and Methods:The institutional review board of each participating institution approved this retrospective study and waived informed consent . This study was HIPAA compliant. A request for cases through the European Society of Urogenital Radiology network was made to institutions for patients who fi t the requirements outlined by the authors, and a prospective follow-up of recipients was performed. Twenty-four tumors were identifi ed that developed in the renal allograft of 20 patients from 11 institutions who were treated with radiofrequency ablation ( n = 19) or cryoablation ( n = 5) between 2003 and 2010. Maximal diameter of masses was 6-40 mm (median, 19.5 mm). Twenty masses were solid, and four were type 4 cystic masses. Preablation biopsy was performed for solid tumors only. All images and biologic and biopsy reports were retrospectively reviewed. Significant differences were determined by using a paired t test before and after ablation. Results:Mean follow-up was 27.9 months (range, 7-71 months). Histopathologic examination revealed papillary carcinoma in 17 patients and clear cell carcinoma in three. Tumors were successfully treated with ultrasonographic guidance in six patients, with computed tomographic guidance in 10 patients, and with both in four patients. One case of infection of the tumor site and one case of transitory genitofemoral nerve injury were the only reported complications.No signifi cant change of renal function was noted. Subsequent imaging follow-up did not reveal any case of recurrence in the ablative site. Conclusion:Percutaneous thermal ablation of renal tumors occurring in renal grafts is effective, with low morbidity.q RSNA, 2011

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Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 56%

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Cornelis

Buy²,

André³

et al. 2011

Radiology

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“…The present results for the distribution of papillary and nonpapillary RCCs are similar to those published previously. The incidence of renal papillary tumours is significantly higher in HD and transplant populations than in the general population [30], and this risk is also increased in patients with acquired multicystic renal dysplasia [31]. Hoshida et al [32] reported the presence of 36% papillary RCCs (eight of 22) and 60% clear cell RCCs in their series.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma of native kidney in renal transplant recipients

et al. 2006

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“…Our results regarding the distribution of papillary and nonpapillary renal cell carcinomas are similar to those reported in the literature. The incidence of renal papillary tumors is significantly higher in dialysis and transplant populations compared with the general population,26 and this risk is also increased in patients with acquired multicystic renal dysplasia 10. Papillary renal tumors account for only 10% of all renal cell carcinomas in the general population in Europe, whereas clear cell tumors account for 75%.…”

Section: Discussionmentioning

confidence: 99%

De novo renal cell carcinoma of native kidney in renal transplant recipients

Neuzillet

Lay

Luccioni

et al. 2005

Cancer

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BACKGROUND The 10‐year risk of developing a solid malignancy is 20% for kidney transplant recipients. The goal of the current study was to investigate the epidemiology and the diagnostic and prognostic parameters associated with de novo malignancies of the native kidney among transplant recipients at the authors' institution (Department of Urology and Renal Transplantation, Hôpital Salvator, Marseille, France). METHODS The authors reexamined the follow‐up of 933 consecutive transplant recipients at their institution between 1987 and 2003. Immunossupressive therapy was not modified in the event of malignant disease, nor was systematic radiologic monitoring of native kidneys performed. All de novo malignancies of the native kidney were included in the current analysis. RESULTS Among the 933 patients examined, a combined total of 12 malignancies of the native kidney were diagnosed in 11 individuals. For these 11 individuals, the average ages at transplantation and diagnosis were 42.5 and 49.1 years, respectively. Ten malignancies were discovered fortuitously, whereas two were symptomatic. Among the 10 renal echographies performed, there was 1 false‐negative result. Tomodensitometry was performed in 11 cases and yielded no false‐negative results. The average tumor size was 37 mm. Nephrectomy was performed in 10 cases, and biopsy was performed in 1. Among the 12 kidney malignancies encountered in the current study, there were 7 conventional cell carcinomas, 3 basophilic papillary carcinomas, and 2 chromophobic renal cell carcinomas. Half of all tumors were Furhman Grade 3 lesions, and pT1aN0M0 tumors (2003 TNM staging system) also accounted for half of all malignancies in the current cohort. Two affected transplant recipients died (one due to disease), and the remaining nine are alive without recurrence and with normal renal functioning (median follow‐up, 39 months). CONCLUSIONS There appears to be an increased risk of malignancy of the native kidney in renal transplant recipients, with high‐grade and papillary tumors being particularly common. Consequently, systematic radiologic follow‐up of native kidneys must be performed for individuals who undergo kidney transplantation. Cancer 2005. © 2004 American Cancer Society.

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Renal cell carcinoma of native kidneys in renal transplant recipients

Cited by 17 publications

References 4 publications

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Renal cell carcinoma of native kidney in renal transplant recipients

De novo renal cell carcinoma of native kidney in renal transplant recipients

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