Renal cell carcinoma presenting as multilocular cystic mass

Laperrière, J; Filion, R; Houde, Michèle; Charghi, Ali

doi:10.1016/0090-4295(86)90111-1

Cited by 15 publications

(5 citation statements)

References 5 publications

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“…Imaging, percutaneous tissue biopsy and cyst aspiration cannot differentiate a multilocular cyst from multicystic renal cell carcinoma, adenocarcinoma, or Wilms' tumour [1,9,10]. Thus the management of this lesion, for diagnostic accuracy as well as for treatment, is either by total nephrectomy or partial nephron sparing surgery [1,7,8].…”

Section: Resultsmentioning

confidence: 99%

The diagnostic dilemma of a multilocular renal cyst: a case report

2009

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IntroductionRenal cysts presenting in childhood are rare. Historically, renal cysts have been subject to variable nomenclature which has contributed to diagnostic difficulties. They can occur as solitary, unilateral or multiple lesions. Cysts can be further classified according to loculation, communications within the structure and tissue types present.Case presentationWe report the case of a 15-month-old Caucasian boy presenting with abdominal distension as the only clinical symptom. On examination, an ill-defined abdominal mass was found. This was confirmed on ultrasound to be a multiseptated cystic mass with a solid element, arising from the right side of the abdomen. Despite further imaging, the origin of the mass could not be identified. The mass was suspected of malignancy but all blood tests and tumour markers were normal. The mass proved to be a diagnostic challenge. The renal origin of the mass was only confirmed at surgery.ConclusionImaging appears to be unreliable in differentiating benign cysts from malignant renal tumours, raising a diagnostic dilemma where surgery seems the only way to reliably establish aetiology of the mass.

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Section: Resultsmentioning

confidence: 99%

The diagnostic dilemma of a multilocular renal cyst: a case report

2009

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“…The coexistence of renal cell carcinomas and cysts has been well documented (34–36). Acquired non‐neoplastic renal cysts are thought to originate from various parts of the nephron, but mostly from the proximal tubule (25).…”

Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma: a clinicopathological, immuno‐ and lectin histochemical study of nine cases

Imura

Ichikawa

Takeda

et al. 2004

APMIS

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Multilocular cystic renal cell carcinoma (MCRCC) is an uncommon variant of renal neoplasm and its histogenesis is unclear. The aim of this study was to use immuno- and lectin histochemistry to delineate histochemical patterns which might indicate the histogenetic origin of MCRCC from a particular part or parts of the nephron. We present our experience with nine cases of MCRCC. Fifteen cases of renal cell carcinoma with cystic degeneration (RCC-CD) were selected for comparison with MCRCC. We carried out clinicopathological and immunohistochemical examinations of the MCRCC cases. Clinically, the prognosis of the patients was quite good, in that all nine patients are alive and without recurrence at the time of this report. The MCRCCs reacted strongly in a higher proportion of cases with the distal nephron markers, such as peanut agglutinin (PNA, 88.9%) and MUC1-core antibody (MUC1, 100%), but none reacted preferentially with proximal nephron markers such as vimentin, Leu M1 and Lotus tetragonolobus (LTA). The RCC-CD tumours reacted with vimentin (40%), Leu M1 (66.7%) and LTA (86.7%). Except for two cases, the RCC-CD tumours did not react with PNA or MUC1 core antibody. These results illustrate the different patterns of expression of MCRCC and RCC-CD and suggest that MCRCC originates from the distal nephron. Therefore, MCRCC should be differentiated from other types of renal cell carcinoma on the basis of the histogenesis of the tumour and the clinicopathological findings.

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“…The multiloculated cystic .mass in the adult can be either a macrocystic RCC or a multilocular cystic nephroma. Their radiologic appearances are very similar (3,6,14). Also, the radiologic differentiation of cystic RCC from benign cystic neoplasms and non-neoplastic cystic masses (trauma, inflammation) may be difficult (1, 8,9).…”

Section: Discussionmentioning

confidence: 99%

Cystic Renal Cell Carcinoma

Yamashita¹,

Watanabe²,

Miyazaki³

et al. 1994

Acta Radiol

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Twenty-seven cystic renal cell carcinomas (RCC) in 23 patients were analyzed radiologically and histologically. They were classified into 4 histopathologic growth patterns: a) multilocular (n = 15, 9 with macrocystic and 6 with microcystic components); b) unilocular (n = 3); c) cystic necrosis (n= 9); and d) tumors originating in the wall of a simple cyst (n = O ) . Macrocystic multilocular RCC showed multiloculated configuration on ultrasound and contrast enhanced CT. Angiography revealed neovascularity peripherally or within the tumor (719 tumors). Microcystic multilocular RCC did not fulfill the criterion for a cystic mass on ultrasound: they were irregularly hyperechoic. There was little enhancement on postcontrast CT and only slight neovascularity on angiography. Unilocular RCC showed a cystic mass with an irregular wall or mural nodules on ultrasound and contrast enhanced CT. Necrotic RCC showed various sono-. graphic findings from anechoic to irregular echoic. The appearance on CT varied from cystic with mural nodules to a multiloculated or irregular architecture. Neovascularity was seen in the periphery in 8 of 9 tumors. Clinically, this type seemed to be the most aggressive. K q words: Kidney neoplasms; ultrasound; -, CT: -, angiography; --, MR imaging. Acta Radiol Downloaded from informahealthcare.com by University of Toronto on 01/02/15 For personal use only.

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Renal cell carcinoma presenting as multilocular cystic mass

Cited by 15 publications

References 5 publications

The diagnostic dilemma of a multilocular renal cyst: a case report

The diagnostic dilemma of a multilocular renal cyst: a case report

Multilocular cystic renal cell carcinoma: a clinicopathological, immuno‐ and lectin histochemical study of nine cases

Cystic Renal Cell Carcinoma

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