Renal cell carcinoma risk associated with lower intake of micronutrients

Abstract

Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample (P‐interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC.

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

“…Furthermore, a diet rich in micronutrients, including selenium, may help to reduce the overall risk of renal cell carcinoma [6]. There are also data suggesting that selenocysteine could be further developed as novel nutritionally available agents to antagonize cisplatin-induced nephrotoxicity during cancer therapy [19].…”

“…Our results showed Se concentrations below 70 μg/L in younger patients using MMF, which is significant for both patients and clinicians, due to the increased risk of cancer development [ 20 , 21 ]. Furthermore, a diet rich in micronutrients, including selenium, may help to reduce the overall risk of renal cell carcinoma [ 6 ]. There are also data suggesting that selenocysteine could be further developed as novel nutritionally available agents to antagonize cisplatin-induced nephrotoxicity during cancer therapy [ 19 ].…”

Components of one-carbon metabolism and renal cell carcinoma: a systematic review and meta-analysis

“…Population diversity is lacking in the studies included in this meta-analysis, with a strong overrepresentation of participants of European descent, largely from affluent countries. Bock et al did compare European-American and African-American participants and found similar associations for the two groups [ 19 ]. The Aune 2010 study is the only one from a Latin American country and its relatively low OR for folate intake suggests the presence of heterogeneity across populations [ 18 ], but further studies in diverse populations are required to examine this possibility.…”

“…The 13 papers were published between 1997 and 2018 and they included a total of 13 different study populations (Table 1) [17][18][19][20][21][22][23][24][25][26][27][28][29]. Five of these studies were conducted in Europe, six were in North America, one in Australia, and one in South America.…”

Neoplastic Pathogenesis Associated with Cigarette Carcinogens

“…RCC can be described in five different forms, namely the following clear cell carcinoma (CCC), papillary tumors (PTs), chromophobe tumors (CTs), oncocytomas, and collecting duct. Each of these types has specific histological features and distinguishing locations, which differentiates them from one another [ 19 , 43 ]. CCC is the most abundant type, making up for about 60% of the cases, and is located in the proximal tubule.…”