Renal Complications in Diabetes Mellitus

Davson, J.; Platt, Robert W.

doi:10.1136/bmj.2.4570.310-b

Cited by 9 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The widespread granulomata resemble those found in experimental serum sickness (Rich, 1942), "allergic granulomatosis " (Churg and Strauss, 1951), and many cases of fatal drug sensitivity (Waugh, 1952;O'Brien and Storey, 1954;Rasmussen, 1955;and others). The necrotizing vascular lesions are morphologically similar to those in polyarteritis nodosa of the " microscopic " variety (Davson et al, 1948), "hypersensitivity angiitis" (Zeek, 1952(Zeek, , 1953, and experimental hypersensitivity (Rich and Gregory, 1943;McKeown, 1947;Crawford and Nassim, 1951;Germuth et al, 1955;and others). As Fahey et al (1954) have remarked, Wegener's granulomatosis closely resembles, both clinically and pathologically, several other uncommon diseases " which run in a spectrum from pure necrotizing and granulomatous processes without vasculitis through mixed forms to pure arteritis without granulomas."…”

Section: 1958mentioning

confidence: 70%

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Walton¹

1958

BMJ

830

282

View full text Add to dashboard Cite

show abstract

Section: 1958mentioning

confidence: 70%

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Walton¹

1958

BMJ

830

282

View full text Add to dashboard Cite

show abstract

“…In contrast, no clear relationship between CGN and lymphoid hyperplasia of spleen was observed (Fig. 5 (20,21). Death is mainly due to active extrarenal vasculitis in classic PN, whereas it is generally due to renal failure in microscopic PN.…”

Section: Methodsmentioning

confidence: 92%

Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis.

Kinjoh

Kyogoku

Good

1993

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

We have established a recombinant inbred strain of mouse named spontaneous crescentic glomerulonephritis-forming mouse/Kinjoh or SCG/Kj. Mice of this strain spontaneously develop rapidly progressive glomerulonephritis.This strain of mice was derived from (BXSB/Mp x MRL/Mplprllpr)Fl hybrid mice by brother x sister mating coupled with repeated histopathologic selection for breeding of mice whose parents had the highest frequency of crescent formation in the kidneys. In this strain of mice, nephritis appears earlier and is more rapidly progressive than in any other murine model of systemic lupus erythematosus. Histopathologically, the characteristic renal lesions in the mice of this strain express a most dramatic form of crescentic glomerulonephritis. The lesions in the kidneys show only slight fine granular immune deposits along the glomerular basement membrane associated with remarkable extraglomerular proliferation and hemorrhage in Bowman's space. Although selection was not based on vasculitis, mice of this strain also exhibit a high incidence of necrotizing vasculitis. These vascular lesions involve primarily small arteries and arterioles and many organs and tissues but spare the kidneys. Thus this form of vasculitis has been found to be correlated with the crescentic form of glomerulonephritis but not with lymphoid hyperplasia of the spleen. We conclude that, in this strain of mouse, the rapidly progressive glomerulonephritis is genetically restricted and that this genetic restriction is firmly linked to that responsible for the vasculitis.

show abstract

“…Although the designation microscopic PAN appeared relatively early in the medical literature [3], that particular form of systemic vasculitis was individualized by Davson et al [4] only in sensus conference [2].…”

Section: Classificationmentioning

confidence: 98%

Advances in the Treatments of Systemic Vasculitides

Guillevin

2008

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Necrotizing systemic vasculitides are severe diseases in which prognosis improved since steroids and cytotoxic agents have been prescribed. The outcome is now better, and remission is obtained in more than 80% of patients. In this review paper, we will cover the indications of conventional treatments and new biotherapies and other therapies. The strategies that improve patient's outcome are discussed in the light of the prospective trials organized by international research groups.

show abstract

Renal Complications in Diabetes Mellitus

Cited by 9 publications

References 0 publications

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis.

Advances in the Treatments of Systemic Vasculitides

Contact Info

Product

Resources

About