Renal damage in experimentally‐induced cirrhosis in rats

Abstract

Cirrhosis with ascites is associated with impaired renal function accompanied by sodium and water retention. Although it has been suggested that mediators such as nitric oxide play a role in the development of renal failure in this situation, other mechanisms underlying the process are not well understood. This study examined the role of oxidative stress in mediating renal damage during the development of cirrhosis in order to understand mechanisms involved in the process. It was shown that carbon tetrachloride-or thioacetamide-induced cirrhosis in rats results in oxidative stress in the kidney as seen by increased lipid peroxidation and protein oxidation, accompanied by altered antioxidant status. Cirrhosis was also found to affect renal mitochondrial function, as assessed by measurement of the respiratory control ratio, the swelling of mitochondria, and calcium flux across mitochondrial membranes. Increased lipid peroxidation and changes in lipid composition were evident in the renal brush border membranes, with compromised transport of 14 C glucose across these membranes. In conclusion, renal alterations produced as a result of cirrhosis in the rat are possibly mediated by oxidative stress. (HEPATOLOGY 2006;43:1248-1256

Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure

“…All these changes are in accordance with previous reports regarding the hemodynamics and renal function in rats with hepatic failure. [27][28][29][30] Taking together, these data confirmed that we successfully established an animal model of functional renal failure in rats with FHF. To exclude effects of the systemic circulation on renal function, we simultaneously monitored SBP of animal models in order to exclude the prerenal azotemia.…”

“…The EM preparation of renal cortex specimens was performed as described previously 27 and the sections were observed in JEOL JEM 1230 Transmission Electron Microscope.…”

Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats

“…However, renal pathology during liver cirrhosis has not been well documented (Natarajan et al, 2006). This study demonstrates that the kidney is damaged and renal macrophage activation is disrupted in rats with liver cirrhosis.…”

Isolation of Astragaloside-IV and Cyclocephaloside-I from Astragalus gummifera and Evaluation of Astragaloside-IV on CCl4 Induced Liver Damage in Rats

“…It is well documented CCl 4 increased creatinine liver and kidney tissues (Simko et al, 1992). The increase in serum creatinine after CCl 4 treatment suggested the abnormal renal function in cirrhotic rats (Natarajan et al, 2006). It is well documented that uric acid in blood is the most important antioxidant and impairment in kidney function that can result from oxidative stress (Khan et al, 2009).…”