Renal Disease and Drug Therapy in Rheumatoid Arthritis

Reduced glomerular function in rheumatoid arthritis.

“…The surveys of autopsy material by Lawson and Maclean (1966) and Burry, de Jersey, and Weedon (1966) revealed that there was a high degree of correlation between total doses of phenacetin-containing analgesics and the incidence of papillary necrosis. Lawson and Maclean (1966) noted an apparent excess of renal disease in rheumatoid arthritics treated with salicylates compared with controls, but were not able to give figures for the salicylate consumption of the controls.…”

Salicylates and renal function in rheumatoid arthritis.

“…Nevertheless, about two-thirds of patients relapse during the first year, and about half of these eventually die with a tumour resistant to chemotherapy.' 2 Attempts to prevent relapse by intensifying chemotherapy have so far proved unsuccessful.' 3 4Evidence for the existance of tumourdirected immunological reactions and their correlation with clinical status',-prompted us to evaluate immunotherapy in a controlled randomised trial.…”

Renal disease in rheumatoid arthritis.

“…6 Nevertheless, it is difficult to differentiate between the disease itself and drug treatment as the cause of the renal damage.…”