Renal Diseases

Parsegian, Karo; Trivedi, Ruchir; Ioannidou, Effie

doi:10.1002/9781119597797.ch16

Cited by 2 publications

(2 citation statements)

References 286 publications

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“…23 The abnormalities in serum urea and creatinine values caused by diabetes and periodontitis were, however, markedly reduced and returned to normal following intraperitoneal delivery of black seed oil. A similar outcome was obtained by Okoye and Igwilo 39 Al-Seeniaet al 37 , Elkhateeb et al 65 , Parsegian et al 66 Thymoquinone and nigellidine, together with other bioactive substances, present in NS, that support the immune system, reduce the risk of cellular damage by activating the body's antioxidant defense mechanism. Researchers' interest in NS screening for novel bioactive chemicals has increased because of its potential medicinal benefits.…”

Section: Effects Of Nigella Sativa Oil On Serum Urea and Creatinine L...supporting

confidence: 72%

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

2023

TJNPR

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Periodontitis can exacerbate and promote the progression of chronic kidney disease through direct or indirect processes such as the impact of periodontal pathogens, antigens, endotoxins, and chronic inflammatory load produced by released cytokines. [11][12][13][14][15] When the pancreas fails to create enough insulin or when the body has difficulties utilizing the insulin that is produced, diabetes mellitus (DM), a chronic illness, can arise. Insulin is the hormone that regulates blood sugar. Hyperglycemia, a symptom of this metabolic and endocrine condition, results from either inadequate insulin synthesis by the pancreas (DM type 1) or incorrect insulin response by the pancreas (DM type 2), and it is defined by elevated blood glucose levels. 16,17 Diabetes mellitus (DM) is a condition that has serious side effects. It is a significant global cause of disease and mortality. According to statistics, 2.8% of people worldwide have diabetes, and by 2025, that number is expected to rise to more than 5.4%. 18 Oxidative stress, cardiac problems, renal failure, neuro-degeneration, and immunological dysfunction are all caused by oxidative stress, which is directly linked to the formation of free radicals in diabetes mellitus. 19 Strong evidence exists to back up the idea that diabetes and periodontitis are interdependent, with diabetes increasing the likelihood of developing periodontitis and periodontal inflammation negatively impacting glycemic control. 20,21 Diabetes individuals experience periodontitis three times more frequently than non-diabetics do. 22 Diabetes and periodontitis have both been linked to kidney damage. 15,23 A serious socioeconomic and healthcare issue, kidney dysfunction, particularly Chronic Kidney Disease (CKD), affects almost 7 billion people globally. In the world, 8724 out of every 100,000 individuals have kidney disease, an amount that is ten times greater than cancer patients and surpasses diabetes by 80%; it

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Section: Effects Of Nigella Sativa Oil On Serum Urea and Creatinine L...supporting

confidence: 72%

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

2023

TJNPR

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“…Hemodialysis patients show following oral mucosa changes xerostomia, angular cheilitis, gingivitis, and uremic breath. Possible causes include dehydration, mouth breathing, and high concentration of urea, and failure to breakdown into ammonia [11] . Incidence of acquired perforating diseases in CKD patients was claimed to be high in previous studies, E.A.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of cutaneous manifestations in chronic kidney disease patients with those under dialysis and post-renal transplant patients

Mishra¹,

Mishra²

2019

Int. J. Dermatol. Venereology Leprosy Sci.

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Background: Dermatologic abnormalities are very common in Chronic kidney disease (CKD) patients and significantly impacts quality of life. They range from nearly universal xerosis and pruritus to uncommon conditions like acquired perforating dermatoses and nephrogenic systemic fibrosis. Cutaneous manifestations may vary among CKD patients with those on dialysis or received renaltransplantation. Early recognition of these conditions can significantly reduce the morbidity and mortality of these patients. Objective: To study the skin manifestations in CKD patients and how it differs from those undergoing dialysis or post-renal transplant patients. To find out how skin features vary with the duration of CKD and duration of dialysis. Methods: Institution based descriptive study was conducted in 45 patients with ESRD (patients with irreversible decline in kidney function) of diverse etiology who attended the nephrology or dermatology department. A detailed clinical history was taken and history of any comorbid condition were recorded. A detailed physical and dermatological examination was done in all cases. Dermatological manifestations observed were documented. Results: Total 45 patients (24 male and 21 females) included in this study. All patients present with at least 1 form of skin alteration. The manifestations are different in CKD pts. compared to those on dialysis or post-transplant group & hence need a different approach towards management. Due to prolonged use of immunosuppressant in kidney transplant recipients, opportunistic infections are very common. Conclusion:World is facing an escalate in the incidence of chronic kidney disease (CKD). Dermatologic abnormalities are very common in CKD patients and significantly impacts quality of life. They range from nearly universal xerosis and pruritus to uncommon conditions like acquired perforating dermatoses and nephrogenic systemic fibrosis. Cutaneous manifestations may vary among CKD patients with those on dialysis or received renal-transplantation. Duration of dialysis or time since transplant also affect the cutaneous abnormalities in CKD patients. Early recognition of these conditions can significantly reduce the morbidity and mortality of these patients.

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Renal Diseases

Cited by 2 publications

References 286 publications

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

A comparative study of cutaneous manifestations in chronic kidney disease patients with those under dialysis and post-renal transplant patients

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